Stem cell therapy

Repurposing cell-based regenerative medicine beyond cell replacement

Eleonora Napoli, Trenton Lippert, Cesar V. Borlongan

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Stem cells exhibit simple and naive cellular features, yet their exact purpose for regenerative medicine continues to elude even the most elegantly designed research paradigms from developmental biology to clinical therapeutics. Based on their capacity to divide indefinitely and their dynamic differentiation into any type of tissue, the advent of transplantable stem cells has offered a potential treatment for aging-related and injury-mediated diseases. Recent laboratory evidence has demonstrated that transplanted human neural stem cells facilitate endogenous reparative mechanisms by initiating multiple regenerative processes in the brain neurogenic areas. Within these highly proliferative niches reside a myriad of potent regenerative molecules, including anti-inflammatory cytokines, proteomes, and neurotrophic factors, altogether representing a biochemical cocktail vital for restoring brain function in the aging and diseased brain. Here, we advance the concept of therapeutically repurposing stem cells not towards cell replacement per se, but rather exploiting the cells’ intrinsic properties to serve as the host brain regenerative catalysts.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages87-91
Number of pages5
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1079
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Regenerative Medicine
Cell- and Tissue-Based Therapy
Stem cells
Brain
Stem Cells
Developmental Biology
Neural Stem Cells
Aging of materials
Nerve Growth Factors
Brain Diseases
Proteome
Anti-Inflammatory Agents
Cytokines
Wounds and Injuries
Therapeutics
Tissue
Research
Catalysts
Molecules

Keywords

  • Cell transplantation
  • Endogenous brain repair
  • Neurogenic niches
  • Neurological disorders

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Napoli, E., Lippert, T., & Borlongan, C. V. (2018). Stem cell therapy: Repurposing cell-based regenerative medicine beyond cell replacement. In Advances in Experimental Medicine and Biology (pp. 87-91). (Advances in Experimental Medicine and Biology; Vol. 1079). Springer New York LLC. https://doi.org/10.1007/5584_2018_174

Stem cell therapy : Repurposing cell-based regenerative medicine beyond cell replacement. / Napoli, Eleonora; Lippert, Trenton; Borlongan, Cesar V.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 87-91 (Advances in Experimental Medicine and Biology; Vol. 1079).

Research output: Chapter in Book/Report/Conference proceedingChapter

Napoli, E, Lippert, T & Borlongan, CV 2018, Stem cell therapy: Repurposing cell-based regenerative medicine beyond cell replacement. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1079, Springer New York LLC, pp. 87-91. https://doi.org/10.1007/5584_2018_174
Napoli E, Lippert T, Borlongan CV. Stem cell therapy: Repurposing cell-based regenerative medicine beyond cell replacement. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 87-91. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/5584_2018_174
Napoli, Eleonora ; Lippert, Trenton ; Borlongan, Cesar V. / Stem cell therapy : Repurposing cell-based regenerative medicine beyond cell replacement. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 87-91 (Advances in Experimental Medicine and Biology).
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