Stem cell therapy: Repurposing cell-based regenerative medicine beyond cell replacement

Eleonora Napoli, Trenton Lippert, Cesar V. Borlongan

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


Stem cells exhibit simple and naive cellular features, yet their exact purpose for regenerative medicine continues to elude even the most elegantly designed research paradigms from developmental biology to clinical therapeutics. Based on their capacity to divide indefinitely and their dynamic differentiation into any type of tissue, the advent of transplantable stem cells has offered a potential treatment for aging-related and injury-mediated diseases. Recent laboratory evidence has demonstrated that transplanted human neural stem cells facilitate endogenous reparative mechanisms by initiating multiple regenerative processes in the brain neurogenic areas. Within these highly proliferative niches reside a myriad of potent regenerative molecules, including anti-inflammatory cytokines, proteomes, and neurotrophic factors, altogether representing a biochemical cocktail vital for restoring brain function in the aging and diseased brain. Here, we advance the concept of therapeutically repurposing stem cells not towards cell replacement per se, but rather exploiting the cells’ intrinsic properties to serve as the host brain regenerative catalysts.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages5
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cell transplantation
  • Endogenous brain repair
  • Neurogenic niches
  • Neurological disorders

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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