Stem cell models help crack regional oncohistone codes driving childhood gliomas

Rachel H. Klein, Paul S. Knoepfler

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
JournalCell Stem Cell
Volume28
Issue number5
DOIs
StatePublished - May 6 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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