Stem cell differentiation is regulated by extracellular matrix mechanics

Lucas R. Smith, Sangkyun Cho, Dennis E. Discher

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.

Original languageEnglish (US)
Pages (from-to)16-25
Number of pages10
JournalPhysiology
Volume33
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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