Stem and progenitor cell microenvironment for bone regeneration and repair

Charles C. Lee, Naoki Hirasawa, Katrina G. Garcia, Dinesh Ramanathan, Kee D. Kim

Research output: Contribution to journalArticle

Abstract

Stem cells reside in their native microenvironment, which provides dynamic physical and chemical cues essential to their survival, proliferation and function. A typical cell-based therapeutic approach requires the mesenchymal stem cells (MSC) to depart their native microenvironment, transplant to in-vivo environment, differentiate toward multiple lineages and participate in bone formation. The long-term survival, function and fate of MSC are dependent on the microenvironment in which they are transplanted. Transplantation of morselized autologous bone, which contains both stem cells and their native microenvironment, results in a good clinical outcome. However, implantation of bone graft substitutes does not provide the complete and dynamic microenvironment for MSC. Current bone graft therapeutics may need to be improved further to provide an optimal engineered MSC microenvironment.

Original languageEnglish (US)
Pages (from-to)693-702
Number of pages10
JournalRegenerative Medicine
Volume14
Issue number7
DOIs
StatePublished - Jan 1 2019

Fingerprint

Stem Cell Niche
Bone Regeneration
Stem cells
Mesenchymal Stromal Cells
Bone
Repair
Stem Cells
Transplants
Bone Substitutes
Bone and Bones
Grafts
Autologous Transplantation
Osteogenesis
Cues
Therapeutics

Keywords

  • bone graft substitutes
  • hematopoietic stem cells
  • mesenchymal stem cells
  • microenvironment
  • osteogenesis
  • spinal fusion
  • stem and progenitor cells
  • stem cell niche

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

Cite this

Stem and progenitor cell microenvironment for bone regeneration and repair. / Lee, Charles C.; Hirasawa, Naoki; Garcia, Katrina G.; Ramanathan, Dinesh; Kim, Kee D.

In: Regenerative Medicine, Vol. 14, No. 7, 01.01.2019, p. 693-702.

Research output: Contribution to journalArticle

Lee, Charles C. ; Hirasawa, Naoki ; Garcia, Katrina G. ; Ramanathan, Dinesh ; Kim, Kee D. / Stem and progenitor cell microenvironment for bone regeneration and repair. In: Regenerative Medicine. 2019 ; Vol. 14, No. 7. pp. 693-702.
@article{0dc40db69aa84eeca437f9cb56837b69,
title = "Stem and progenitor cell microenvironment for bone regeneration and repair",
abstract = "Stem cells reside in their native microenvironment, which provides dynamic physical and chemical cues essential to their survival, proliferation and function. A typical cell-based therapeutic approach requires the mesenchymal stem cells (MSC) to depart their native microenvironment, transplant to in-vivo environment, differentiate toward multiple lineages and participate in bone formation. The long-term survival, function and fate of MSC are dependent on the microenvironment in which they are transplanted. Transplantation of morselized autologous bone, which contains both stem cells and their native microenvironment, results in a good clinical outcome. However, implantation of bone graft substitutes does not provide the complete and dynamic microenvironment for MSC. Current bone graft therapeutics may need to be improved further to provide an optimal engineered MSC microenvironment.",
keywords = "bone graft substitutes, hematopoietic stem cells, mesenchymal stem cells, microenvironment, osteogenesis, spinal fusion, stem and progenitor cells, stem cell niche",
author = "Lee, {Charles C.} and Naoki Hirasawa and Garcia, {Katrina G.} and Dinesh Ramanathan and Kim, {Kee D.}",
year = "2019",
month = "1",
day = "1",
doi = "10.2217/rme-2018-0044",
language = "English (US)",
volume = "14",
pages = "693--702",
journal = "Regenerative Medicine",
issn = "1746-0751",
publisher = "Future Medicine Ltd.",
number = "7",

}

TY - JOUR

T1 - Stem and progenitor cell microenvironment for bone regeneration and repair

AU - Lee, Charles C.

AU - Hirasawa, Naoki

AU - Garcia, Katrina G.

AU - Ramanathan, Dinesh

AU - Kim, Kee D.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Stem cells reside in their native microenvironment, which provides dynamic physical and chemical cues essential to their survival, proliferation and function. A typical cell-based therapeutic approach requires the mesenchymal stem cells (MSC) to depart their native microenvironment, transplant to in-vivo environment, differentiate toward multiple lineages and participate in bone formation. The long-term survival, function and fate of MSC are dependent on the microenvironment in which they are transplanted. Transplantation of morselized autologous bone, which contains both stem cells and their native microenvironment, results in a good clinical outcome. However, implantation of bone graft substitutes does not provide the complete and dynamic microenvironment for MSC. Current bone graft therapeutics may need to be improved further to provide an optimal engineered MSC microenvironment.

AB - Stem cells reside in their native microenvironment, which provides dynamic physical and chemical cues essential to their survival, proliferation and function. A typical cell-based therapeutic approach requires the mesenchymal stem cells (MSC) to depart their native microenvironment, transplant to in-vivo environment, differentiate toward multiple lineages and participate in bone formation. The long-term survival, function and fate of MSC are dependent on the microenvironment in which they are transplanted. Transplantation of morselized autologous bone, which contains both stem cells and their native microenvironment, results in a good clinical outcome. However, implantation of bone graft substitutes does not provide the complete and dynamic microenvironment for MSC. Current bone graft therapeutics may need to be improved further to provide an optimal engineered MSC microenvironment.

KW - bone graft substitutes

KW - hematopoietic stem cells

KW - mesenchymal stem cells

KW - microenvironment

KW - osteogenesis

KW - spinal fusion

KW - stem and progenitor cells

KW - stem cell niche

UR - http://www.scopus.com/inward/record.url?scp=85070641512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070641512&partnerID=8YFLogxK

U2 - 10.2217/rme-2018-0044

DO - 10.2217/rme-2018-0044

M3 - Article

C2 - 31393221

AN - SCOPUS:85070641512

VL - 14

SP - 693

EP - 702

JO - Regenerative Medicine

JF - Regenerative Medicine

SN - 1746-0751

IS - 7

ER -