Status epilepticus: Clinical features, pathophysiology, and treatment

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

During the past two decades, substantial progress has been made in the understanding of the clinical features, classification, pathophysiology, central nervous system consequences, and treatment of status epilepticus. The most commonly used drug regimens have advantages and disadvantages, and, in this review, I recommend a protocol for the treatment of status epilepticus. An important concept in the approach to patients in generalized tonic-clonic status epilepticus is that treatment should be administered within a predetermined time frame. Clinical and experimental research indicates that continuous seizure activity for longer than 60 to 90 minutes may result in irreversible brain damage. As our understanding of the basic mechanisms of neuronal function and seizure generation advances, it is expected that more specific and novel approaches to the treatment of status epilepticus will emerge.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalWestern Journal of Medicine
Volume155
Issue number6
StatePublished - 1991
Externally publishedYes

Fingerprint

Status Epilepticus
Seizures
Therapeutics
Clinical Protocols
Central Nervous System
Brain
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Status epilepticus : Clinical features, pathophysiology, and treatment. / Watson, Craig.

In: Western Journal of Medicine, Vol. 155, No. 6, 1991, p. 626-631.

Research output: Contribution to journalArticle

@article{e378ad8993f74c56bf8ed6f6b93c8e3a,
title = "Status epilepticus: Clinical features, pathophysiology, and treatment",
abstract = "During the past two decades, substantial progress has been made in the understanding of the clinical features, classification, pathophysiology, central nervous system consequences, and treatment of status epilepticus. The most commonly used drug regimens have advantages and disadvantages, and, in this review, I recommend a protocol for the treatment of status epilepticus. An important concept in the approach to patients in generalized tonic-clonic status epilepticus is that treatment should be administered within a predetermined time frame. Clinical and experimental research indicates that continuous seizure activity for longer than 60 to 90 minutes may result in irreversible brain damage. As our understanding of the basic mechanisms of neuronal function and seizure generation advances, it is expected that more specific and novel approaches to the treatment of status epilepticus will emerge.",
author = "Craig Watson",
year = "1991",
language = "English (US)",
volume = "155",
pages = "626--631",
journal = "Western Journal of Medicine",
issn = "0093-0415",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Status epilepticus

T2 - Clinical features, pathophysiology, and treatment

AU - Watson, Craig

PY - 1991

Y1 - 1991

N2 - During the past two decades, substantial progress has been made in the understanding of the clinical features, classification, pathophysiology, central nervous system consequences, and treatment of status epilepticus. The most commonly used drug regimens have advantages and disadvantages, and, in this review, I recommend a protocol for the treatment of status epilepticus. An important concept in the approach to patients in generalized tonic-clonic status epilepticus is that treatment should be administered within a predetermined time frame. Clinical and experimental research indicates that continuous seizure activity for longer than 60 to 90 minutes may result in irreversible brain damage. As our understanding of the basic mechanisms of neuronal function and seizure generation advances, it is expected that more specific and novel approaches to the treatment of status epilepticus will emerge.

AB - During the past two decades, substantial progress has been made in the understanding of the clinical features, classification, pathophysiology, central nervous system consequences, and treatment of status epilepticus. The most commonly used drug regimens have advantages and disadvantages, and, in this review, I recommend a protocol for the treatment of status epilepticus. An important concept in the approach to patients in generalized tonic-clonic status epilepticus is that treatment should be administered within a predetermined time frame. Clinical and experimental research indicates that continuous seizure activity for longer than 60 to 90 minutes may result in irreversible brain damage. As our understanding of the basic mechanisms of neuronal function and seizure generation advances, it is expected that more specific and novel approaches to the treatment of status epilepticus will emerge.

UR - http://www.scopus.com/inward/record.url?scp=0026332318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026332318&partnerID=8YFLogxK

M3 - Article

C2 - 1812633

AN - SCOPUS:0026332318

VL - 155

SP - 626

EP - 631

JO - Western Journal of Medicine

JF - Western Journal of Medicine

SN - 0093-0415

IS - 6

ER -