Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation

Masood A. Khan, Richard M. Gallo, Gourapura J. Renukaradhya, Wenjun Du, Jacquelyn Gervay-Hague, Randy R. Brutkiewicz

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Statins are widely used as cholesterol-lowering agents that also decrease inflammation and target enzymes essential for prenylation, an important process in the activation and intracellular transport of proteins vital for a wide variety of cellular functions. Here, we report that statins impair a critical component of the innate immune response, CD1d-mediated Ag presentation. The addition of specific intermediates in the isoprenylation pathway reversed this effect, whereas specific targeting of enzymes responsible for prenylation mimicked the inhibitory effects of statins on Ag presentation by CD1d as well as MHC class II molecules. This study demonstrates the importance of isoprenylation in the regulation of Ag presentation and suggests a mechanism by which statins reduce inflammatory responses.

Original languageEnglish (US)
Pages (from-to)4744-4750
Number of pages7
JournalJournal of Immunology
Volume182
Issue number8
DOIs
StatePublished - Apr 15 2009

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CD1d Antigen
Prenylation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Antigen Presentation
Enzymes
Innate Immunity
Carrier Proteins
Cholesterol
Inflammation

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. / Khan, Masood A.; Gallo, Richard M.; Renukaradhya, Gourapura J.; Du, Wenjun; Gervay-Hague, Jacquelyn; Brutkiewicz, Randy R.

In: Journal of Immunology, Vol. 182, No. 8, 15.04.2009, p. 4744-4750.

Research output: Contribution to journalArticle

Khan, Masood A. ; Gallo, Richard M. ; Renukaradhya, Gourapura J. ; Du, Wenjun ; Gervay-Hague, Jacquelyn ; Brutkiewicz, Randy R. / Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. In: Journal of Immunology. 2009 ; Vol. 182, No. 8. pp. 4744-4750.
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