Static contraction causes a reflex-induced release of arginine vasopressin in anesthetized cats

Lea R. Liviakis, Charles L Stebbins

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We tested the hypothesis that brief static contraction of the triceps surae muscle causes reflex-induced increases in plasma arginine vasopressin (AVP) in anesthetized cats. Arterial blood samples, for measurement of plasma AVP, were taken before and after 30 s of electrically stimulated static contraction performed at a low intensity (<20% of maximal; n = 5), a high intensity (>70% of maximal; n = 7), and a high intensity after denervation of the triceps surae (n = 5). The low intensity contraction protocol was repeated during α-adrenergic blockade (n = 7) to minimize potential baroreflex-induced inhibition of AVP release. Passive stretch of the triceps surae was conducted (n = 5) to determine effects of muscle mechanoreceptor stimulation on the release of AVP. Low intensity contraction had no effect on plasma AVP. During α-adrenergic blockade, this same contraction intensity caused this peptide to increase from12.8 ± 2.1 to 17.7 ± 2.6 pg/ml. High intensity contraction caused an increase in AVP (13.2 ± 3.5 to 26.1 ± 6.6 pg/ml) that was abolished by denervation (14.4 ± 3.7 vs. 17.1 ± 6.6 pg/ml). Passive stretch had no effect on plasma AVP. These findings suggest that brief static contraction causes increases in plasma AVP that are reflex in nature, intensity dependent, opposed by the arterial baroreflex, and probably unrelated to muscle mechanoreceptor activation. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalBrain Research Bulletin
Volume53
Issue number2
DOIs
StatePublished - Sep 15 2000

Fingerprint

Arginine Vasopressin
Reflex
Cats
Mechanoreceptors
Baroreflex
Denervation
Muscles
Adrenergic Agents
Peptides

Keywords

  • α-Adrenergic receptor antagonism
  • Arterial baroreflex
  • Muscle mechanoreceptors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Static contraction causes a reflex-induced release of arginine vasopressin in anesthetized cats. / Liviakis, Lea R.; Stebbins, Charles L.

In: Brain Research Bulletin, Vol. 53, No. 2, 15.09.2000, p. 233-238.

Research output: Contribution to journalArticle

Liviakis, Lea R. ; Stebbins, Charles L. / Static contraction causes a reflex-induced release of arginine vasopressin in anesthetized cats. In: Brain Research Bulletin. 2000 ; Vol. 53, No. 2. pp. 233-238.
@article{2236d8abfd1846219803463b1d3101c9,
title = "Static contraction causes a reflex-induced release of arginine vasopressin in anesthetized cats",
abstract = "We tested the hypothesis that brief static contraction of the triceps surae muscle causes reflex-induced increases in plasma arginine vasopressin (AVP) in anesthetized cats. Arterial blood samples, for measurement of plasma AVP, were taken before and after 30 s of electrically stimulated static contraction performed at a low intensity (<20{\%} of maximal; n = 5), a high intensity (>70{\%} of maximal; n = 7), and a high intensity after denervation of the triceps surae (n = 5). The low intensity contraction protocol was repeated during α-adrenergic blockade (n = 7) to minimize potential baroreflex-induced inhibition of AVP release. Passive stretch of the triceps surae was conducted (n = 5) to determine effects of muscle mechanoreceptor stimulation on the release of AVP. Low intensity contraction had no effect on plasma AVP. During α-adrenergic blockade, this same contraction intensity caused this peptide to increase from12.8 ± 2.1 to 17.7 ± 2.6 pg/ml. High intensity contraction caused an increase in AVP (13.2 ± 3.5 to 26.1 ± 6.6 pg/ml) that was abolished by denervation (14.4 ± 3.7 vs. 17.1 ± 6.6 pg/ml). Passive stretch had no effect on plasma AVP. These findings suggest that brief static contraction causes increases in plasma AVP that are reflex in nature, intensity dependent, opposed by the arterial baroreflex, and probably unrelated to muscle mechanoreceptor activation. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "α-Adrenergic receptor antagonism, Arterial baroreflex, Muscle mechanoreceptors",
author = "Liviakis, {Lea R.} and Stebbins, {Charles L}",
year = "2000",
month = "9",
day = "15",
doi = "10.1016/S0361-9230(00)00331-2",
language = "English (US)",
volume = "53",
pages = "233--238",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Static contraction causes a reflex-induced release of arginine vasopressin in anesthetized cats

AU - Liviakis, Lea R.

AU - Stebbins, Charles L

PY - 2000/9/15

Y1 - 2000/9/15

N2 - We tested the hypothesis that brief static contraction of the triceps surae muscle causes reflex-induced increases in plasma arginine vasopressin (AVP) in anesthetized cats. Arterial blood samples, for measurement of plasma AVP, were taken before and after 30 s of electrically stimulated static contraction performed at a low intensity (<20% of maximal; n = 5), a high intensity (>70% of maximal; n = 7), and a high intensity after denervation of the triceps surae (n = 5). The low intensity contraction protocol was repeated during α-adrenergic blockade (n = 7) to minimize potential baroreflex-induced inhibition of AVP release. Passive stretch of the triceps surae was conducted (n = 5) to determine effects of muscle mechanoreceptor stimulation on the release of AVP. Low intensity contraction had no effect on plasma AVP. During α-adrenergic blockade, this same contraction intensity caused this peptide to increase from12.8 ± 2.1 to 17.7 ± 2.6 pg/ml. High intensity contraction caused an increase in AVP (13.2 ± 3.5 to 26.1 ± 6.6 pg/ml) that was abolished by denervation (14.4 ± 3.7 vs. 17.1 ± 6.6 pg/ml). Passive stretch had no effect on plasma AVP. These findings suggest that brief static contraction causes increases in plasma AVP that are reflex in nature, intensity dependent, opposed by the arterial baroreflex, and probably unrelated to muscle mechanoreceptor activation. Copyright (C) 2000 Elsevier Science Inc.

AB - We tested the hypothesis that brief static contraction of the triceps surae muscle causes reflex-induced increases in plasma arginine vasopressin (AVP) in anesthetized cats. Arterial blood samples, for measurement of plasma AVP, were taken before and after 30 s of electrically stimulated static contraction performed at a low intensity (<20% of maximal; n = 5), a high intensity (>70% of maximal; n = 7), and a high intensity after denervation of the triceps surae (n = 5). The low intensity contraction protocol was repeated during α-adrenergic blockade (n = 7) to minimize potential baroreflex-induced inhibition of AVP release. Passive stretch of the triceps surae was conducted (n = 5) to determine effects of muscle mechanoreceptor stimulation on the release of AVP. Low intensity contraction had no effect on plasma AVP. During α-adrenergic blockade, this same contraction intensity caused this peptide to increase from12.8 ± 2.1 to 17.7 ± 2.6 pg/ml. High intensity contraction caused an increase in AVP (13.2 ± 3.5 to 26.1 ± 6.6 pg/ml) that was abolished by denervation (14.4 ± 3.7 vs. 17.1 ± 6.6 pg/ml). Passive stretch had no effect on plasma AVP. These findings suggest that brief static contraction causes increases in plasma AVP that are reflex in nature, intensity dependent, opposed by the arterial baroreflex, and probably unrelated to muscle mechanoreceptor activation. Copyright (C) 2000 Elsevier Science Inc.

KW - α-Adrenergic receptor antagonism

KW - Arterial baroreflex

KW - Muscle mechanoreceptors

UR - http://www.scopus.com/inward/record.url?scp=0034665589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034665589&partnerID=8YFLogxK

U2 - 10.1016/S0361-9230(00)00331-2

DO - 10.1016/S0361-9230(00)00331-2

M3 - Article

VL - 53

SP - 233

EP - 238

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 2

ER -