State-of-the-art methods in clinical intracochlear drug delivery

Oliver Y. Chin, Rodney C Diaz

Research output: Contribution to journalReview article

Abstract

Purpose of reviewIncreasing awareness and prevalence of disorders in hearing and balance have placed emphasis on treatment strategies. With the rapid evolution in molecular, gene, and nanotechnology, alternate delivery methods have advanced intracochlear drug delivery. This review aims to raise awareness of recent developments in technologies to augment current clinical practices.Recent findingsIntracochlear drug delivery research has expanded with the familiarity and accessibility to cochlear implantation. Various therapeutics are closely studied for both safety and efficacy as well as biologic effect. Agents including neurotrophins, antiapoptotics, cell therapy, gene therapy, and anti-inflammatory drugs are on the forefront of preclinical research. Cochlear implant electrode modification and drug administration at the time of implantation is a major focus of research. Improvements in study design have focused on overcoming barriers including elucidating the role of the blood-perilymph barrier.SummaryInner ear drug delivery methods include systemic, intratympanic, and intracochlear administration. Therapeutic technologies aim to overcome delivery barriers and to improve overall biologic effect while minimizing toxicity. Precision of drug application through intratympanic and intracochlear administration with minimal trauma is the future of inner ear drug development.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume27
Issue number5
DOIs
StatePublished - Oct 1 2019

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Pharmaceutical Preparations
Research
Perilymph
Hearing Disorders
Technology
Cochlear Implantation
Nanotechnology
Cochlear Implants
Molecular Evolution
Nerve Growth Factors
Inner Ear
Cell- and Tissue-Based Therapy
Genetic Therapy
Ear
Electrodes
Anti-Inflammatory Agents
Therapeutics
Safety
Wounds and Injuries
Genes

Keywords

  • direct intracochlear drug
  • indirect intracochlear drug
  • inner ear drug
  • otic drug

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

State-of-the-art methods in clinical intracochlear drug delivery. / Chin, Oliver Y.; Diaz, Rodney C.

In: Current Opinion in Otolaryngology and Head and Neck Surgery, Vol. 27, No. 5, 01.10.2019, p. 381-386.

Research output: Contribution to journalReview article

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