SRY negative 64,XX intersex phenotype in an American saddlebred horse

Danika L Bannasch, C. Rinaldo, L. Millon, K. Latson, T. Spangler, S. Hubberty, Larry D Galuppo, Linda J Lowenstine

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalVeterinary Journal
Volume173
Issue number2
DOIs
StatePublished - Mar 2007

Fingerprint

Horses
Phenotype
horses
phenotype
46, XX Testicular Disorders of Sex Development
Spermatogonia
Genitalia
spermatogonia
sex reversal
stallions
Karyotype
karyotyping
genitalia
complement
polymerase chain reaction
Polymerase Chain Reaction
American Saddlebred
blood
Genes
tissues

Keywords

  • Equine
  • Karyotype
  • Pseudohermaphrodite
  • SRY gene
  • XX-sex reversal

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

SRY negative 64,XX intersex phenotype in an American saddlebred horse. / Bannasch, Danika L; Rinaldo, C.; Millon, L.; Latson, K.; Spangler, T.; Hubberty, S.; Galuppo, Larry D; Lowenstine, Linda J.

In: Veterinary Journal, Vol. 173, No. 2, 03.2007, p. 437-439.

Research output: Contribution to journalArticle

Bannasch, Danika L ; Rinaldo, C. ; Millon, L. ; Latson, K. ; Spangler, T. ; Hubberty, S. ; Galuppo, Larry D ; Lowenstine, Linda J. / SRY negative 64,XX intersex phenotype in an American saddlebred horse. In: Veterinary Journal. 2007 ; Vol. 173, No. 2. pp. 437-439.
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