SRY negative 64,XX intersex phenotype in an American saddlebred horse

Danika L Bannasch, C. Rinaldo, L. Millon, K. Latson, T. Spangler, S. Hubberty, Larry D Galuppo, Linda J Lowenstine

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalVeterinary Journal
Volume173
Issue number2
DOIs
StatePublished - Mar 2007

Keywords

  • Equine
  • Karyotype
  • Pseudohermaphrodite
  • SRY gene
  • XX-sex reversal

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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