Abstract
A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-439 |
| Number of pages | 3 |
| Journal | Veterinary Journal |
| Volume | 173 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2007 |
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Keywords
- Equine
- Karyotype
- Pseudohermaphrodite
- SRY gene
- XX-sex reversal
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
SRY negative 64,XX intersex phenotype in an American saddlebred horse. / Bannasch, Danika L; Rinaldo, C.; Millon, L.; Latson, K.; Spangler, T.; Hubberty, S.; Galuppo, Larry D; Lowenstine, Linda J.
In: Veterinary Journal, Vol. 173, No. 2, 03.2007, p. 437-439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SRY negative 64,XX intersex phenotype in an American saddlebred horse
AU - Bannasch, Danika L
AU - Rinaldo, C.
AU - Millon, L.
AU - Latson, K.
AU - Spangler, T.
AU - Hubberty, S.
AU - Galuppo, Larry D
AU - Lowenstine, Linda J
PY - 2007/3
Y1 - 2007/3
N2 - A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
AB - A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
KW - Equine
KW - Karyotype
KW - Pseudohermaphrodite
KW - SRY gene
KW - XX-sex reversal
UR - http://www.scopus.com/inward/record.url?scp=33847069143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847069143&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2005.11.008
DO - 10.1016/j.tvjl.2005.11.008
M3 - Article
C2 - 16386440
AN - SCOPUS:33847069143
VL - 173
SP - 437
EP - 439
JO - Veterinary Journal
JF - Veterinary Journal
SN - 1090-0233
IS - 2
ER -