Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays

D. Dosev, M. Nichkova, R. K. Dumas, Kai Liu, I. M. Kennedy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsD.V. Nicolau
Volume6036
DOIs
StatePublished - 2006
EventBioMEMS and Nanotechnology II - Brisbane, Australia
Duration: Dec 12 2005Dec 14 2005

Other

OtherBioMEMS and Nanotechnology II
CountryAustralia
CityBrisbane
Period12/12/0512/14/05

ASJC Scopus subject areas

  • Engineering(all)

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    Dosev, D., Nichkova, M., Dumas, R. K., Liu, K., & Kennedy, I. M. (2006). Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays. In D. V. Nicolau (Ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6036). [60360T] https://doi.org/10.1117/12.638599