Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays

D. Dosev; M. Nichkova; R. K. Dumas; Kai Liu; I. M. Kennedy

doi:10.1117/12.638599

Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays

D. Dosev, M. Nichkova, R. K. Dumas, Kai Liu, I. M. Kennedy

Mechanical and Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd ₂O ₃). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd ₂O ₃ host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	D.V. Nicolau
Volume	6036
DOIs	https://doi.org/10.1117/12.638599
State	Published - 2006
Event	BioMEMS and Nanotechnology II - Brisbane, Australia Duration: Dec 12 2005 → Dec 14 2005

Other

Other	BioMEMS and Nanotechnology II
Country/Territory	Australia
City	Brisbane
Period	12/12/05 → 12/14/05

ASJC Scopus subject areas

Engineering(all)

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10.1117/12.638599

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Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays. / Dosev, D.; Nichkova, M.; Dumas, R. K.; Liu, Kai; Kennedy, I. M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / D.V. Nicolau. Vol. 6036 2006. 60360T.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dosev, D, Nichkova, M, Dumas, RK, Liu, K & Kennedy, IM 2006, Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays. in DV Nicolau (ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6036, 60360T, BioMEMS and Nanotechnology II, Brisbane, Australia, 12/12/05. https://doi.org/10.1117/12.638599

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abstract = "Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes. ",

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AU - Liu, Kai

AU - Kennedy, I. M.

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AB - Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.

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Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays

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