Abstract
Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.
Original language | English (US) |
---|---|
Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Editors | D.V. Nicolau |
Volume | 6036 |
DOIs | |
State | Published - 2006 |
Event | BioMEMS and Nanotechnology II - Brisbane, Australia Duration: Dec 12 2005 → Dec 14 2005 |
Other
Other | BioMEMS and Nanotechnology II |
---|---|
Country/Territory | Australia |
City | Brisbane |
Period | 12/12/05 → 12/14/05 |
ASJC Scopus subject areas
- Engineering(all)