Abstract
Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Editors | D.V. Nicolau |
| Volume | 6036 |
| DOIs | |
| State | Published - 2006 |
| Event | BioMEMS and Nanotechnology II - Brisbane, Australia Duration: Dec 12 2005 → Dec 14 2005 |
Other
| Other | BioMEMS and Nanotechnology II |
|---|---|
| Country | Australia |
| City | Brisbane |
| Period | 12/12/05 → 12/14/05 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays. / Dosev, D.; Nichkova, M.; Dumas, R. K.; Liu, Kai; Kennedy, I. M.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / D.V. Nicolau. Vol. 6036 2006. 60360T.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties. Application of magnetic/luminescent particles in immunoassays
AU - Dosev, D.
AU - Nichkova, M.
AU - Dumas, R. K.
AU - Liu, Kai
AU - Kennedy, I. M.
PY - 2006
Y1 - 2006
N2 - Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.
AB - Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements by Vibrating Sample Magnetometry showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd 2O 3 host - a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.
UR - http://www.scopus.com/inward/record.url?scp=33645235316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645235316&partnerID=8YFLogxK
U2 - 10.1117/12.638599
DO - 10.1117/12.638599
M3 - Conference contribution
AN - SCOPUS:33645235316
VL - 6036
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
A2 - Nicolau, D.V.
ER -