Spray pyrolysis synthesis of particles possessing magnetic and fluorescent properties. Application of magnetic/fluorescent particles in immunoassays

D. Dosev; M. Nichkova; R. Dumas; K. Liu; I. M. Kennedy

Spray pyrolysis synthesis of particles possessing magnetic and fluorescent properties. Application of magnetic/fluorescent particles in immunoassays

D. Dosev, M. Nichkova, R. Dumas, K. Liu, I. M. Kennedy

Mechanical and Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Many types of fluorescent nanoparticles have been synthesized as alternatives to organic dyes in biochemistry. Magnetic beads also have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of particle that has both fluorescent and magnetic properties. The particles have magnetic cores of iron oxide and a fluorescent shell of europium - doped gadolinium oxide (Eu:Gd ₂O ₃). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response behavior of the composite particles. Fluorescence spectroscopy showed fluorescent spectra typical for the Eu ion in a Gd ₂O ₃ host with a narrow emission peak centered near 615 nm. Our synthesis method provides a low-cost, high-rate synthesis that allows a wide range of biological applications of magnetic/fluorescent core/shell particles. We show an immunoassay using the fluorescent properties of the particles.

Original language	English (US)
Title of host publication	AIChE Annual Meeting, Conference Proceedings
Pages	11352-11364
Number of pages	13
State	Published - 2005
Event	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States Duration: Oct 30 2005 → Nov 4 2005

Other

Other	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
Country	United States
City	Cincinnati, OH
Period	10/30/05 → 11/4/05

ASJC Scopus subject areas

Engineering(all)

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Dosev, D, Nichkova, M, Dumas, R, Liu, K & Kennedy, IM 2005, Spray pyrolysis synthesis of particles possessing magnetic and fluorescent properties. Application of magnetic/fluorescent particles in immunoassays. in AIChE Annual Meeting, Conference Proceedings. pp. 11352-11364, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05.

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abstract = "Many types of fluorescent nanoparticles have been synthesized as alternatives to organic dyes in biochemistry. Magnetic beads also have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of particle that has both fluorescent and magnetic properties. The particles have magnetic cores of iron oxide and a fluorescent shell of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response behavior of the composite particles. Fluorescence spectroscopy showed fluorescent spectra typical for the Eu ion in a Gd 2O 3 host with a narrow emission peak centered near 615 nm. Our synthesis method provides a low-cost, high-rate synthesis that allows a wide range of biological applications of magnetic/fluorescent core/shell particles. We show an immunoassay using the fluorescent properties of the particles.",

author = "D. Dosev and M. Nichkova and R. Dumas and K. Liu and Kennedy, {I. M.}",

year = "2005",

language = "English (US)",

pages = "11352--11364",

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note = "05AIChE: 2005 AIChE Annual Meeting and Fall Showcase ; Conference date: 30-10-2005 Through 04-11-2005",

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AU - Dosev, D.

AU - Nichkova, M.

AU - Dumas, R.

AU - Liu, K.

AU - Kennedy, I. M.

PY - 2005

Y1 - 2005

N2 - Many types of fluorescent nanoparticles have been synthesized as alternatives to organic dyes in biochemistry. Magnetic beads also have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of particle that has both fluorescent and magnetic properties. The particles have magnetic cores of iron oxide and a fluorescent shell of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response behavior of the composite particles. Fluorescence spectroscopy showed fluorescent spectra typical for the Eu ion in a Gd 2O 3 host with a narrow emission peak centered near 615 nm. Our synthesis method provides a low-cost, high-rate synthesis that allows a wide range of biological applications of magnetic/fluorescent core/shell particles. We show an immunoassay using the fluorescent properties of the particles.

AB - Many types of fluorescent nanoparticles have been synthesized as alternatives to organic dyes in biochemistry. Magnetic beads also have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of particle that has both fluorescent and magnetic properties. The particles have magnetic cores of iron oxide and a fluorescent shell of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response behavior of the composite particles. Fluorescence spectroscopy showed fluorescent spectra typical for the Eu ion in a Gd 2O 3 host with a narrow emission peak centered near 615 nm. Our synthesis method provides a low-cost, high-rate synthesis that allows a wide range of biological applications of magnetic/fluorescent core/shell particles. We show an immunoassay using the fluorescent properties of the particles.

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Y2 - 30 October 2005 through 4 November 2005

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