Spray pyrolysis synthesis of particles possessing magnetic and fluorescent properties. Application of magnetic/fluorescent particles in immunoassays

D. Dosev, M. Nichkova, R. Dumas, K. Liu, I. M. Kennedy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many types of fluorescent nanoparticles have been synthesized as alternatives to organic dyes in biochemistry. Magnetic beads also have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of particle that has both fluorescent and magnetic properties. The particles have magnetic cores of iron oxide and a fluorescent shell of europium - doped gadolinium oxide (Eu:Gd 2O 3). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response behavior of the composite particles. Fluorescence spectroscopy showed fluorescent spectra typical for the Eu ion in a Gd 2O 3 host with a narrow emission peak centered near 615 nm. Our synthesis method provides a low-cost, high-rate synthesis that allows a wide range of biological applications of magnetic/fluorescent core/shell particles. We show an immunoassay using the fluorescent properties of the particles.

Original languageEnglish (US)
Title of host publicationAIChE Annual Meeting, Conference Proceedings
Pages11352-11364
Number of pages13
StatePublished - 2005
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

ASJC Scopus subject areas

  • Engineering(all)

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    Dosev, D., Nichkova, M., Dumas, R., Liu, K., & Kennedy, I. M. (2005). Spray pyrolysis synthesis of particles possessing magnetic and fluorescent properties. Application of magnetic/fluorescent particles in immunoassays. In AIChE Annual Meeting, Conference Proceedings (pp. 11352-11364)