Abstract
Importance: Granuloma annulare is typically a benign, self-limited disease. Atypical presentations have been reported in association with systemic disease, including malignancy. Such patients may require additional diagnostic studies to assess for underlying malignancy. We report a patient with extensive sporotrichoid granuloma annulare-like dermatitis in association with systemic B-cell lymphoma. Observations: An 83-year-old man with a three-year history of progressive sporotrichoid annular plaques and nodules on the arm developed ipsilateral retroauricular palpable lymphadenopathy, the latter consistent with B-cell lymphoma. Multiple skin biopsies of the plaques and nodules revealed granuloma annulare-like dermatitis. Lesions were unresponsive to intralesional and intramuscular corticosteroids, antibiotics, and antifungal agents, but rapidly improved following initiation of rituximab to treat his underlying lymphoma. Conclusions and Relevance: Atypical presentations of granuloma annulare including granuloma annulare-like dermatitis warrant evaluation for systemic malignancy in a subset of patients.
| Original language | English (US) |
|---|---|
| Article number | 4 |
| Journal | Dermatology Online Journal |
| Volume | 21 |
| Issue number | 9 |
| State | Published - Sep 1 2015 |
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Keywords
- B-cell lymphoma
- Granuloma annulare
- Malignancy
ASJC Scopus subject areas
- Dermatology
Cite this
Sporotrichoid granuloma annulare-like dermatitis associated with systemic B-cell lymphoma. / Fisk, Whitney A.; Millsop, Jillian W.; Johnson, Mary Ann; Konia, Thomas; Fung, Maxwell A; Sharon, Victoria R.
In: Dermatology Online Journal, Vol. 21, No. 9, 4, 01.09.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sporotrichoid granuloma annulare-like dermatitis associated with systemic B-cell lymphoma
AU - Fisk, Whitney A.
AU - Millsop, Jillian W.
AU - Johnson, Mary Ann
AU - Konia, Thomas
AU - Fung, Maxwell A
AU - Sharon, Victoria R.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Importance: Granuloma annulare is typically a benign, self-limited disease. Atypical presentations have been reported in association with systemic disease, including malignancy. Such patients may require additional diagnostic studies to assess for underlying malignancy. We report a patient with extensive sporotrichoid granuloma annulare-like dermatitis in association with systemic B-cell lymphoma. Observations: An 83-year-old man with a three-year history of progressive sporotrichoid annular plaques and nodules on the arm developed ipsilateral retroauricular palpable lymphadenopathy, the latter consistent with B-cell lymphoma. Multiple skin biopsies of the plaques and nodules revealed granuloma annulare-like dermatitis. Lesions were unresponsive to intralesional and intramuscular corticosteroids, antibiotics, and antifungal agents, but rapidly improved following initiation of rituximab to treat his underlying lymphoma. Conclusions and Relevance: Atypical presentations of granuloma annulare including granuloma annulare-like dermatitis warrant evaluation for systemic malignancy in a subset of patients.
AB - Importance: Granuloma annulare is typically a benign, self-limited disease. Atypical presentations have been reported in association with systemic disease, including malignancy. Such patients may require additional diagnostic studies to assess for underlying malignancy. We report a patient with extensive sporotrichoid granuloma annulare-like dermatitis in association with systemic B-cell lymphoma. Observations: An 83-year-old man with a three-year history of progressive sporotrichoid annular plaques and nodules on the arm developed ipsilateral retroauricular palpable lymphadenopathy, the latter consistent with B-cell lymphoma. Multiple skin biopsies of the plaques and nodules revealed granuloma annulare-like dermatitis. Lesions were unresponsive to intralesional and intramuscular corticosteroids, antibiotics, and antifungal agents, but rapidly improved following initiation of rituximab to treat his underlying lymphoma. Conclusions and Relevance: Atypical presentations of granuloma annulare including granuloma annulare-like dermatitis warrant evaluation for systemic malignancy in a subset of patients.
KW - B-cell lymphoma
KW - Granuloma annulare
KW - Malignancy
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M3 - Article
C2 - 26437282
AN - SCOPUS:84941766346
VL - 21
JO - Dermatology Online Journal
JF - Dermatology Online Journal
SN - 1087-2108
IS - 9
M1 - 4
ER -