Spore biomarker detection using a MEMS differential mobility spectrometer

Cristina E Davis, J. M. Kang, C. E. Dubé, J. T. Borenstein, E. G. Nazarov, R. A. Miller, A. M. Zapata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

Early detection technologies permit quick characterization of a bioweapons threat and identification of a hoax that will minimize human casualties and reduce the time and financial burdens associated with containment, triage and clean up. In this paper, we demonstrate that distinctive biological markers are present in pyrolyzed Bacillus endospore samples and these volatile chemical signatures can be detected by differential ion mobility spectrometry (DMS). The known endospore biomarker 2,6-pyridine-dicarboxylic acid (dipicolinic acid) can be detected by our micromachined DMS device, and Bacillus spore biomarkers are detected by DMS after pyrolysis.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1233-1237
Number of pages5
Volume2
ISBN (Print)0780377311, 9780780377318
DOIs
StatePublished - 2003
Externally publishedYes
Event12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers - Boston, United States
Duration: Jun 8 2003Jun 12 2003

Other

Other12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers
Country/TerritoryUnited States
CityBoston
Period6/8/036/12/03

Keywords

  • Biomarkers
  • Chemicals
  • Fungi
  • Laboratories
  • Magnetic analysis
  • Micromechanical devices
  • Pathogens
  • Spectroscopy
  • Testing
  • Weapons

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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