Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling

Lalage M. Wakefield, Gudmundur Thordarson, Ana I. Nieto, G. Shyamala, Jose J. Galvez, Miriam R. Anver, Robert Cardiff

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40% of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material. The prevalence of this phenotype further increased with age. The mammary phenotype was highly correlated with the presence of proliferative, prolactin-secreting lesions in the pituitary gland. In mice aged 18 to 23 months, hyperplasia of the pars distalis was seen in 11 of 21 mice (52%), and a further 4 of 21 mice (19%) had pituitary adenomas. Pituitary hyperplasia was already evident in some mice as young as nine months. The pituitary phenotype was also associated with high prevalence (4/6 mice) of spontaneous mammary tumors in aged multiparous, but not virgin FVB/NCr mice. This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain.

Original languageEnglish (US)
Pages (from-to)424-432
Number of pages9
JournalComparative Medicine
Volume53
Issue number4
StatePublished - Aug 1 2003

Fingerprint

hyperplasia
breasts
Hyperplasia
Breast
mice
Prolactin
Ducts
Tumors
mammary glands
Human Mammary Glands
phenotype
Phenotype
animal models
genetically modified organisms
pituitary gland
adenoma
mammary neoplasms (animal)
virgin females
prolactin
Pituitary Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Wakefield, L. M., Thordarson, G., Nieto, A. I., Shyamala, G., Galvez, J. J., Anver, M. R., & Cardiff, R. (2003). Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling. Comparative Medicine, 53(4), 424-432.

Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice : Implications for mouse modeling. / Wakefield, Lalage M.; Thordarson, Gudmundur; Nieto, Ana I.; Shyamala, G.; Galvez, Jose J.; Anver, Miriam R.; Cardiff, Robert.

In: Comparative Medicine, Vol. 53, No. 4, 01.08.2003, p. 424-432.

Research output: Contribution to journalArticle

Wakefield, LM, Thordarson, G, Nieto, AI, Shyamala, G, Galvez, JJ, Anver, MR & Cardiff, R 2003, 'Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling', Comparative Medicine, vol. 53, no. 4, pp. 424-432.
Wakefield LM, Thordarson G, Nieto AI, Shyamala G, Galvez JJ, Anver MR et al. Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling. Comparative Medicine. 2003 Aug 1;53(4):424-432.
Wakefield, Lalage M. ; Thordarson, Gudmundur ; Nieto, Ana I. ; Shyamala, G. ; Galvez, Jose J. ; Anver, Miriam R. ; Cardiff, Robert. / Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice : Implications for mouse modeling. In: Comparative Medicine. 2003 ; Vol. 53, No. 4. pp. 424-432.
@article{64c25a9d983246e59a831487af041fa8,
title = "Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling",
abstract = "The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40{\%} of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material. The prevalence of this phenotype further increased with age. The mammary phenotype was highly correlated with the presence of proliferative, prolactin-secreting lesions in the pituitary gland. In mice aged 18 to 23 months, hyperplasia of the pars distalis was seen in 11 of 21 mice (52{\%}), and a further 4 of 21 mice (19{\%}) had pituitary adenomas. Pituitary hyperplasia was already evident in some mice as young as nine months. The pituitary phenotype was also associated with high prevalence (4/6 mice) of spontaneous mammary tumors in aged multiparous, but not virgin FVB/NCr mice. This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain.",
author = "Wakefield, {Lalage M.} and Gudmundur Thordarson and Nieto, {Ana I.} and G. Shyamala and Galvez, {Jose J.} and Anver, {Miriam R.} and Robert Cardiff",
year = "2003",
month = "8",
day = "1",
language = "English (US)",
volume = "53",
pages = "424--432",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "4",

}

TY - JOUR

T1 - Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice

T2 - Implications for mouse modeling

AU - Wakefield, Lalage M.

AU - Thordarson, Gudmundur

AU - Nieto, Ana I.

AU - Shyamala, G.

AU - Galvez, Jose J.

AU - Anver, Miriam R.

AU - Cardiff, Robert

PY - 2003/8/1

Y1 - 2003/8/1

N2 - The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40% of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material. The prevalence of this phenotype further increased with age. The mammary phenotype was highly correlated with the presence of proliferative, prolactin-secreting lesions in the pituitary gland. In mice aged 18 to 23 months, hyperplasia of the pars distalis was seen in 11 of 21 mice (52%), and a further 4 of 21 mice (19%) had pituitary adenomas. Pituitary hyperplasia was already evident in some mice as young as nine months. The pituitary phenotype was also associated with high prevalence (4/6 mice) of spontaneous mammary tumors in aged multiparous, but not virgin FVB/NCr mice. This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain.

AB - The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40% of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material. The prevalence of this phenotype further increased with age. The mammary phenotype was highly correlated with the presence of proliferative, prolactin-secreting lesions in the pituitary gland. In mice aged 18 to 23 months, hyperplasia of the pars distalis was seen in 11 of 21 mice (52%), and a further 4 of 21 mice (19%) had pituitary adenomas. Pituitary hyperplasia was already evident in some mice as young as nine months. The pituitary phenotype was also associated with high prevalence (4/6 mice) of spontaneous mammary tumors in aged multiparous, but not virgin FVB/NCr mice. This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain.

UR - http://www.scopus.com/inward/record.url?scp=0141813442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141813442&partnerID=8YFLogxK

M3 - Article

C2 - 14524419

AN - SCOPUS:0141813442

VL - 53

SP - 424

EP - 432

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 4

ER -