Spontaneous lung chemiluminescence upon paraquat administration

Julio F. Turrens, Cecilia R Giulivi, Claudia R. Pinus, Carla Lavagno, Alberto Boveris

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

In vivo rat lung chemiluminescence was measured at different times after a single injection of either 30 or 60 mg paraquat/kg b.w. The lungs were isolated to determine myeloperoxidase (index of polymorphonuclear leukocytes0, lung wet weight (lung edema) and malondialdehyde (lipid peroxidation). The highest chemiluminecence was reached 30 hours after injection of 30 mkg/kg or 6 hours after a 60 mg/kg dose. The peak chemiluminescence was coincident with the maximum concentration of myeloperoxidase and lung wet weight suggesting that most chemiluminescence was the consequence of polymorphonuclear activation after migration to the injured areas.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalFree Radical Biology and Medicine
Volume5
Issue number5-6
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • Chemiluminescence
  • Free radicals
  • Lipid Peroxidation
  • Lung
  • Oxygen toxicity
  • Paraquat

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine(all)
  • Toxicology

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