Spontaneous intrahepatic hemorrhage and hepatic rupture in the HELLP syndrome: Four cases and a review

Rafiq A. Sheikh, Shagufta Yasmeen, Mary Pat Pauly, Jonathan L. Riegler

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Subcapsular hemorrhage and hepatic rupture are unusual catastrophic complications of the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. A high index of suspicion and prompt recognition are keys to proper diagnosis and management of affected patients. The optimal management of these patients is evolving. An aggressive multidisciplinary approach has considerably improved the morbidity and mortality associated with these complications. We present our experience with four cases of hepatic hemorrhage occurring in association with the HELLP syndrome and review the literature on this subject. All of our patients were multiparous, and three had a history of eclampsia/preeclampsia in a previous pregnancy. All four patients developed intrahepatic hemorrhage; two developed hepatic rupture requiring surgical intervention. Three patients developed disseminated intravascular coagulation and acute renal failure. Two patients developed pericardial effusion, pleural effusions, and ascites. One patient died of septic complications after multiple surgical interventions.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume28
Issue number4
DOIs
StatePublished - Jun 1999

Keywords

  • HELLP syndrome
  • Hepatic rupture
  • Intrahepatic hemorrhage
  • Subcapsular hematoma

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Spontaneous intrahepatic hemorrhage and hepatic rupture in the HELLP syndrome: Four cases and a review'. Together they form a unique fingerprint.

  • Cite this