Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.)

C. R. Valverde, R. P. Tarara, Stephen M Griffey, Jeffrey A Roberts

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background and Purpose: Intestinal adenocarcinoma appears to be the most common malignant neoplasm in macaques, and is a substantial cause of morbidity and mortality in the elderly. Methods: A retrospective review of 32 cases was done. Results: Thirty-two cases were reviewed. Clinical examination had revealed severe weight loss, anorexia, and palpable abdominal mass. Microcytic hypochromic anemia, intermittent fecal occult blood positive test results, hypoproteinemia, and hypoalbuminemia were the predominant clinical laboratory findings. Carcinoembryogenic antigen serologic testing and single-strand conformational polymorphism analysis were performed in selected cases. The most common sites of the intestinal adenocarcinoma were ileocecal junction, colon, ileum, jejunum, and cecum. Metastases were evident in 34% of the cases and involved peripheral nodes, liver, lungs, pancreas, and adrenal gland. Overall survival of 12 macaques that underwent surgical excision was 83% at 6 months, 58% at 1 year, 50% at 1.5 years, 33% at 2 years, and 8% at 4 years. The overall mean survival rate (MSR) was > 483 postoperative days. Conclusion: Intestinal adenocarcinomas should be amenable to surgical resection. Early detection of localized, non-invasive neoplasms will increase surgical cure rate. Survivability could be potentially improved by use of adjuvant therapies.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalComparative Medicine
Volume50
Issue number5
StatePublished - 2000

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Geriatrics
Clinical laboratories
Macaca
adenocarcinoma
Polymorphism
Liver
Adenocarcinoma
Blood
Antigens
Testing
Hypoproteinemia
Hypoalbuminemia
Occult Blood
neoplasms
single-stranded conformational polymorphism
excision
Cecum
adrenal glands
Anorexia
Hematologic Tests

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.). / Valverde, C. R.; Tarara, R. P.; Griffey, Stephen M; Roberts, Jeffrey A.

In: Comparative Medicine, Vol. 50, No. 5, 2000, p. 540-544.

Research output: Contribution to journalArticle

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