Spontaneous activity of morphologically identified ganglion cells in the developing ferret retina

Lauren C. Liets, Bruno A. Olshausen, Guo Yong Wang, Leo M. Chalupa

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Whole-cell patch-clamp recordings were made from morphologically identified ganglion cells in the intact retina of developing ferrets. As early as 3 d after birth, all ganglion cells exhibited bursts of spontaneous activity, with the interval between bursts gradually decreasing with maturity. By 2 weeks after birth, ganglion cells could be morphologically differentiated into three major classes (α, β, and γ), and at this time each cell class was characterized by a distinct pattern of spontaneous activity. Dual patch-clamp recordings from pairs of neighboring cells revealed that cells of all morphological classes burst in a coordinated manner, regardless of cell type. These observations suggest that a common mechanism underlies the bursting patterns exhibited by all ganglion cell classes, and that class-specific firing patterns emerge coincident with retinal ganglion cell morphological differentiation.

Original languageEnglish (US)
Pages (from-to)7343-7350
Number of pages8
JournalJournal of Neuroscience
Volume23
Issue number19
DOIs
StatePublished - Aug 13 2003

Keywords

  • Dual patch-clamp
  • Ganglion cells
  • Retina
  • Retinal development
  • Spontaneous activity
  • Synchronous activity

ASJC Scopus subject areas

  • Neuroscience(all)

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