Spindle neurons of the human anterior cingul. Ate cortex

Esther A. Nimchinsky, Brent A. Vogt, John Morrison, Patrick R. Hof

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

The human anterior cingulate cortex is distinguished by the presence of an unusual cell type, a large spindle neuron in layer Vb. This cell has been noted numerous times in the historical literature but has not been studied with modern neuroanatomic techniques. For instance, details regarding the neuronal class to which these cells belong and regarding their precise distribution along both ventrodorsal and anteroposterior axes of the cingulate gyrus are still lacking. In the present study, morphological features and the anatomic distribution of this cell type were studied using computer‐assisted mapping and immunocytochemical techniques. Spindle neurons are restricted to the subfields; of the anterior cingulate cortex (Brodmann's area 24), exhibiting a greater density in anterior portions of this area than in posterior portions, and tapering off in the transition zone between anterior and posterior cingulate cortex. Furthermore, a majority of the spindle cells at any level is located in subarea 24b on the gyral surface. Immunocytochemical analysis revealed that the neurofilament protein triplet was present in a large percentage of these neurons and that they did not contain calcium‐binding proteins. Injections of the carbocyanine dye DiI into the cingulum bundle revealed that these cells are projection neurons. Finally, spindle cells were consistently affected in Alzheimer's disease cases, with an overall loss of about 60%. Taken together, these observations indicate that the spindle cells of the human cingulate cortex represent a morphological subpopulation of pyramidal neurons whose restricted distribution may be associated with functionally distinct areas.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalJournal of Comparative Neurology
Volume355
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Gyrus Cinguli
Neurons
Neurofilament Proteins
Pyramidal Cells
Alzheimer Disease
Coloring Agents
Injections
Proteins

Keywords

  • cerebral cortex
  • cytoarchitecture
  • human brain
  • neurofilament protein
  • neuron
  • pyramidal

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spindle neurons of the human anterior cingul. Ate cortex. / Nimchinsky, Esther A.; Vogt, Brent A.; Morrison, John; Hof, Patrick R.

In: Journal of Comparative Neurology, Vol. 355, No. 1, 01.01.1995, p. 27-37.

Research output: Contribution to journalArticle

Nimchinsky, Esther A. ; Vogt, Brent A. ; Morrison, John ; Hof, Patrick R. / Spindle neurons of the human anterior cingul. Ate cortex. In: Journal of Comparative Neurology. 1995 ; Vol. 355, No. 1. pp. 27-37.
@article{dddbbd3cd9c441aab8a5eb5646b924c8,
title = "Spindle neurons of the human anterior cingul. Ate cortex",
abstract = "The human anterior cingulate cortex is distinguished by the presence of an unusual cell type, a large spindle neuron in layer Vb. This cell has been noted numerous times in the historical literature but has not been studied with modern neuroanatomic techniques. For instance, details regarding the neuronal class to which these cells belong and regarding their precise distribution along both ventrodorsal and anteroposterior axes of the cingulate gyrus are still lacking. In the present study, morphological features and the anatomic distribution of this cell type were studied using computer‐assisted mapping and immunocytochemical techniques. Spindle neurons are restricted to the subfields; of the anterior cingulate cortex (Brodmann's area 24), exhibiting a greater density in anterior portions of this area than in posterior portions, and tapering off in the transition zone between anterior and posterior cingulate cortex. Furthermore, a majority of the spindle cells at any level is located in subarea 24b on the gyral surface. Immunocytochemical analysis revealed that the neurofilament protein triplet was present in a large percentage of these neurons and that they did not contain calcium‐binding proteins. Injections of the carbocyanine dye DiI into the cingulum bundle revealed that these cells are projection neurons. Finally, spindle cells were consistently affected in Alzheimer's disease cases, with an overall loss of about 60{\%}. Taken together, these observations indicate that the spindle cells of the human cingulate cortex represent a morphological subpopulation of pyramidal neurons whose restricted distribution may be associated with functionally distinct areas.",
keywords = "cerebral cortex, cytoarchitecture, human brain, neurofilament protein, neuron, pyramidal",
author = "Nimchinsky, {Esther A.} and Vogt, {Brent A.} and John Morrison and Hof, {Patrick R.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1002/cne.903550106",
language = "English (US)",
volume = "355",
pages = "27--37",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Spindle neurons of the human anterior cingul. Ate cortex

AU - Nimchinsky, Esther A.

AU - Vogt, Brent A.

AU - Morrison, John

AU - Hof, Patrick R.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The human anterior cingulate cortex is distinguished by the presence of an unusual cell type, a large spindle neuron in layer Vb. This cell has been noted numerous times in the historical literature but has not been studied with modern neuroanatomic techniques. For instance, details regarding the neuronal class to which these cells belong and regarding their precise distribution along both ventrodorsal and anteroposterior axes of the cingulate gyrus are still lacking. In the present study, morphological features and the anatomic distribution of this cell type were studied using computer‐assisted mapping and immunocytochemical techniques. Spindle neurons are restricted to the subfields; of the anterior cingulate cortex (Brodmann's area 24), exhibiting a greater density in anterior portions of this area than in posterior portions, and tapering off in the transition zone between anterior and posterior cingulate cortex. Furthermore, a majority of the spindle cells at any level is located in subarea 24b on the gyral surface. Immunocytochemical analysis revealed that the neurofilament protein triplet was present in a large percentage of these neurons and that they did not contain calcium‐binding proteins. Injections of the carbocyanine dye DiI into the cingulum bundle revealed that these cells are projection neurons. Finally, spindle cells were consistently affected in Alzheimer's disease cases, with an overall loss of about 60%. Taken together, these observations indicate that the spindle cells of the human cingulate cortex represent a morphological subpopulation of pyramidal neurons whose restricted distribution may be associated with functionally distinct areas.

AB - The human anterior cingulate cortex is distinguished by the presence of an unusual cell type, a large spindle neuron in layer Vb. This cell has been noted numerous times in the historical literature but has not been studied with modern neuroanatomic techniques. For instance, details regarding the neuronal class to which these cells belong and regarding their precise distribution along both ventrodorsal and anteroposterior axes of the cingulate gyrus are still lacking. In the present study, morphological features and the anatomic distribution of this cell type were studied using computer‐assisted mapping and immunocytochemical techniques. Spindle neurons are restricted to the subfields; of the anterior cingulate cortex (Brodmann's area 24), exhibiting a greater density in anterior portions of this area than in posterior portions, and tapering off in the transition zone between anterior and posterior cingulate cortex. Furthermore, a majority of the spindle cells at any level is located in subarea 24b on the gyral surface. Immunocytochemical analysis revealed that the neurofilament protein triplet was present in a large percentage of these neurons and that they did not contain calcium‐binding proteins. Injections of the carbocyanine dye DiI into the cingulum bundle revealed that these cells are projection neurons. Finally, spindle cells were consistently affected in Alzheimer's disease cases, with an overall loss of about 60%. Taken together, these observations indicate that the spindle cells of the human cingulate cortex represent a morphological subpopulation of pyramidal neurons whose restricted distribution may be associated with functionally distinct areas.

KW - cerebral cortex

KW - cytoarchitecture

KW - human brain

KW - neurofilament protein

KW - neuron

KW - pyramidal

UR - http://www.scopus.com/inward/record.url?scp=0029007601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029007601&partnerID=8YFLogxK

U2 - 10.1002/cne.903550106

DO - 10.1002/cne.903550106

M3 - Article

C2 - 7636011

AN - SCOPUS:0029007601

VL - 355

SP - 27

EP - 37

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 1

ER -