Spinal radiosurgery: Delayed radiation-induced myelopathy

Megan E Daly, Iris C. Gibbs

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Spinal cord dose parameters to minimize the risk of radiation myelopathy are relatively well-defined in the conventionally fractionated setting, but remain controversial for the high dose-per-fraction, partial-cord dosimetry encountered in stereotactic radiosurgery (SRS). Myelopathy has been only rarely described in the setting of SRS, and a variety of suggested dose constraints exist in the literature, ranging from a maximum cord dose (cord Dmax) of 10 to 14 Gy or a partial volume tolerance of 10 Gy (V10) to 10% of the contoured cord. Ever-improving attempts at normal tissue complication probability (NCTP) modeling permit estimation of the potential toxicity of high dose-per-fraction regimens, while animal models provide additional insights on a partial cord volume tolerance model for radiation myelopathy and suggest regional differences in radiation sensitivity across the spinal cord. The literature to date contains only ten reported cases of SRS-induced myelopathy; however, with increasing use of SRS for both benign and metastatic lesions of the spine, refining our understanding of the tolerance of the human spinal cord to hypofractionated dosimetry remains crucial.

Original languageEnglish (US)
Title of host publicationTumors of the1 Central Nervous System, Volume 6
Subtitle of host publicationSpinal Tumors (Part 1)
PublisherSpringer Netherlands
Pages135-140
Number of pages6
ISBN (Electronic)9789400728660
ISBN (Print)9789400728653
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Daly, M. E., & Gibbs, I. C. (2012). Spinal radiosurgery: Delayed radiation-induced myelopathy. In Tumors of the1 Central Nervous System, Volume 6: Spinal Tumors (Part 1) (pp. 135-140). Springer Netherlands. https://doi.org/10.1007/978-94-007-2866-0_17