Spinal oligodendroglioma with gliomatosis in a child: Case report

Holly S. Gilmer-Hill, William G. Ellis, Steven G. Imbesi, James E Boggan

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The authors present a rare case of oligodendrogliomatosis in a child, which they believe originated from a primary spinal cord tumor. At 2.5 years of age this boy developed poor balance, neck stiffness, and a regression in developmental milestones. A computerized tomography (CT) scan of the head initially revealed ventriculomegaly and multiple cystic cerebellar lesions. In addition, magnetic resonance (MR) imaging revealed a cystic intramedullary lesion involving the cervical spinal cord. ACT scan of the head and an MR image obtained 3 years later demonstrated diffuse small cysts on the surface of the brainstem, cerebellum, medial temporal and inferior frontal cortices, subcortical white matter, and corpus callosum suggestive of leptomeningeal tumor spread. Analysis of pathological specimens obtained at surgery showed neoplastic glial cells with small, uniform nuclei and perinuclear clear zones. The cells appeared to migrate along the subpial space but no tumor cells were present in the subarachnoid space. These findings were compatible with a diagnosis of oligodendrogliomatosis cerebri. Despite having a complicated course, chemotherapy with carboplatin has provided the patient with long-term palliation and a high quality of life. This case may represent the fifth report in the literature of oligodendrogliomatosis occurring in a child but only the third occurring with a spinal primary tumor.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalJournal of Neurosurgery
Issue number1 SUPPL.
StatePublished - Jan 2000


  • Gliomatosis cerebri
  • Leptomeningeal gliomatosis
  • Oligodendrogliomatosis
  • Spinal oligodendroglioma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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