Spinal c-fos expression associated with spontaneous biting in a mouse model of dry skin pruritus

Hiroshi Nojima, Jason M. Cuellar, Christopher T. Simons, Mirela Iodi Carstens, Earl Carstens

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

As a model of dry skin pruritus in mice, one hind paw was treated twice daily with a mixture of acetone/diethylether/water (AEW); controls received water only. A protective collar prevented the animals from accessing the treatment area. At 16 days, the collar was removed and AEW-treated mice exhibited marked biting of the treated paw; the number and cumulative duration of bites was significantly greater than in controls. After 3 additional treatment days (collars intact), animals were perfused for c-fos immunohistochemistry. There was significantly more fos-like immunoreactivity in the ipsilateral lumbar spinal cord of AEW-treated animals, with the majority in superficial laminae. It is proposed that biting of the dry skin reflects pruritus, and that neurons predominantly in superficial laminae of the dorsal horn may signal itch sensation.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalNeuroscience Letters
Volume361
Issue number1-3
DOIs
StatePublished - May 6 2004

Keywords

  • Biting
  • Dry skin
  • Itch
  • Pruritus
  • Scratching
  • Superficial dorsal horn

ASJC Scopus subject areas

  • Neuroscience(all)

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