Spillover and pandemic properties of zoonotic viruses with high host plasticity

Christine K Johnson, Peta L. Hitchens, Tierra Smiley Evans, Tracey Goldstein, Kate Thomas, Andrew Clements, Damien O. Joly, Nathan D. Wolfe, Peter Daszak, William B. Karesh, Jonna A Mazet

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ongoing disease transmission from animals to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification, and spread of diseases is essential for prioritizing surveillance and predicting future disease emergence risk. We examine the animal hosts and transmission mechanisms involved in spillover of zoonotic viruses to date, and discover that viruses with high host plasticity (i.e. taxonomically and ecologically diverse host range) were more likely to amplify viral spillover by secondary human-to-human transmission and have broader geographic spread. Viruses transmitted to humans during practices that facilitate mixing of diverse animal species had significantly higher host plasticity. Our findings suggest that animal-to-human spillover of new viruses that are capable of infecting diverse host species signal emerging disease events with higher pandemic potential in that these viruses are more likely to amplify by human-to-human transmission with spread on a global scale.

Original languageEnglish (US)
Article number14830
JournalScientific Reports
Volume5
DOIs
StatePublished - Oct 7 2015

Fingerprint

Zoonoses
Pandemics
Viruses
Animal Diseases
Host Specificity
Communicable Diseases

ASJC Scopus subject areas

  • General

Cite this

Spillover and pandemic properties of zoonotic viruses with high host plasticity. / Johnson, Christine K; Hitchens, Peta L.; Smiley Evans, Tierra; Goldstein, Tracey; Thomas, Kate; Clements, Andrew; Joly, Damien O.; Wolfe, Nathan D.; Daszak, Peter; Karesh, William B.; Mazet, Jonna A.

In: Scientific Reports, Vol. 5, 14830, 07.10.2015.

Research output: Contribution to journalArticle

Johnson, CK, Hitchens, PL, Smiley Evans, T, Goldstein, T, Thomas, K, Clements, A, Joly, DO, Wolfe, ND, Daszak, P, Karesh, WB & Mazet, JA 2015, 'Spillover and pandemic properties of zoonotic viruses with high host plasticity', Scientific Reports, vol. 5, 14830. https://doi.org/10.1038/srep14830
Johnson, Christine K ; Hitchens, Peta L. ; Smiley Evans, Tierra ; Goldstein, Tracey ; Thomas, Kate ; Clements, Andrew ; Joly, Damien O. ; Wolfe, Nathan D. ; Daszak, Peter ; Karesh, William B. ; Mazet, Jonna A. / Spillover and pandemic properties of zoonotic viruses with high host plasticity. In: Scientific Reports. 2015 ; Vol. 5.
@article{04ff1a4a33f24006890d38874fb9c8e2,
title = "Spillover and pandemic properties of zoonotic viruses with high host plasticity",
abstract = "Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ongoing disease transmission from animals to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification, and spread of diseases is essential for prioritizing surveillance and predicting future disease emergence risk. We examine the animal hosts and transmission mechanisms involved in spillover of zoonotic viruses to date, and discover that viruses with high host plasticity (i.e. taxonomically and ecologically diverse host range) were more likely to amplify viral spillover by secondary human-to-human transmission and have broader geographic spread. Viruses transmitted to humans during practices that facilitate mixing of diverse animal species had significantly higher host plasticity. Our findings suggest that animal-to-human spillover of new viruses that are capable of infecting diverse host species signal emerging disease events with higher pandemic potential in that these viruses are more likely to amplify by human-to-human transmission with spread on a global scale.",
author = "Johnson, {Christine K} and Hitchens, {Peta L.} and {Smiley Evans}, Tierra and Tracey Goldstein and Kate Thomas and Andrew Clements and Joly, {Damien O.} and Wolfe, {Nathan D.} and Peter Daszak and Karesh, {William B.} and Mazet, {Jonna A}",
year = "2015",
month = "10",
day = "7",
doi = "10.1038/srep14830",
language = "English (US)",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Spillover and pandemic properties of zoonotic viruses with high host plasticity

AU - Johnson, Christine K

AU - Hitchens, Peta L.

AU - Smiley Evans, Tierra

AU - Goldstein, Tracey

AU - Thomas, Kate

AU - Clements, Andrew

AU - Joly, Damien O.

AU - Wolfe, Nathan D.

AU - Daszak, Peter

AU - Karesh, William B.

AU - Mazet, Jonna A

PY - 2015/10/7

Y1 - 2015/10/7

N2 - Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ongoing disease transmission from animals to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification, and spread of diseases is essential for prioritizing surveillance and predicting future disease emergence risk. We examine the animal hosts and transmission mechanisms involved in spillover of zoonotic viruses to date, and discover that viruses with high host plasticity (i.e. taxonomically and ecologically diverse host range) were more likely to amplify viral spillover by secondary human-to-human transmission and have broader geographic spread. Viruses transmitted to humans during practices that facilitate mixing of diverse animal species had significantly higher host plasticity. Our findings suggest that animal-to-human spillover of new viruses that are capable of infecting diverse host species signal emerging disease events with higher pandemic potential in that these viruses are more likely to amplify by human-to-human transmission with spread on a global scale.

AB - Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ongoing disease transmission from animals to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification, and spread of diseases is essential for prioritizing surveillance and predicting future disease emergence risk. We examine the animal hosts and transmission mechanisms involved in spillover of zoonotic viruses to date, and discover that viruses with high host plasticity (i.e. taxonomically and ecologically diverse host range) were more likely to amplify viral spillover by secondary human-to-human transmission and have broader geographic spread. Viruses transmitted to humans during practices that facilitate mixing of diverse animal species had significantly higher host plasticity. Our findings suggest that animal-to-human spillover of new viruses that are capable of infecting diverse host species signal emerging disease events with higher pandemic potential in that these viruses are more likely to amplify by human-to-human transmission with spread on a global scale.

UR - http://www.scopus.com/inward/record.url?scp=84943327552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943327552&partnerID=8YFLogxK

U2 - 10.1038/srep14830

DO - 10.1038/srep14830

M3 - Article

C2 - 26445169

AN - SCOPUS:84943327552

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 14830

ER -