Sphingomyelin lipidosis (Niemann-Pick Disease) in a juvenile raccoon (Procyon lotor)

Natalia Vapniarsky Arzi, D. A. Wenger, D. Scheenstra, Asli Mete

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A wild caught juvenile male raccoon with neurological disease was humanely destroyed due to poor prognosis. Necropsy examination revealed hepatomegaly, splenomegaly and multicentric lymphadenomegaly with diffuse hepatic pallor and pulmonary consolidation with pinpoint pale subpleural foci. Microscopically, there was marked pale cytoplasmic swelling of the central and peripheral neurons as well as the glial cells in the brain, accompanied by multiorgan infiltration by abundant foamy macrophages. Ultrastructural investigation revealed accumulation of concentrically arranged lamellar material within lysosomes of the affected neurons, macrophages and endothelial cells. Biochemical enzymatic analysis detected sphingomyelinase deficiency and lysosomal storage disease consistent with sphingomyelin lipidosis (Niemann-Pick disease [NPD]) was diagnosed. This is the first report of NPD in a raccoon.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalJournal of Comparative Pathology
Volume149
Issue number2-3
DOIs
StatePublished - Aug 2013

Fingerprint

Type A Niemann-Pick Disease
Niemann-Pick Diseases
Raccoons
sphingomyelins
Procyon lotor
macrophages
neurons
Macrophages
Lysosomal Storage Diseases
Pallor
Neurons
splenomegaly
Hepatomegaly
Splenomegaly
neuroglia
lysosomes
Lysosomes
Neuroglia
endothelial cells
prognosis

Keywords

  • Lysosomal storage disease
  • Niemann-Pick disease
  • Raccoon
  • Sphingomyelinase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Sphingomyelin lipidosis (Niemann-Pick Disease) in a juvenile raccoon (Procyon lotor). / Vapniarsky Arzi, Natalia; Wenger, D. A.; Scheenstra, D.; Mete, Asli.

In: Journal of Comparative Pathology, Vol. 149, No. 2-3, 08.2013, p. 385-389.

Research output: Contribution to journalArticle

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