Spherical aberration yielding optimum visual performance: Evaluation of intraocular lenses using adaptive optics simulation

John S Werner, Sarah L. Elliott, Stacey S. Choi, Nathan Doble

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: To evaluate the influence of spherical aberration on contrast sensitivity using adaptive optics. Setting: Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology & Vision Science, University of California, Davis Medical Center, Sacramento, California, USA. Methods: Contrast sensitivity at 8 cycles per degree was evaluated using an adaptive optics system that permitted aberrations to be measured with a Hartmann-Shack wavefront sensor and controlled by a 109 actuator continuous-surface deformable mirror that was at a plane conjugate to the observer's pupil. Vertical Gabor patches were viewed through a 6.3 mm diameter pupil conjugate aperture. Contrast sensitivity was measured with the deformable mirror set to produce 1 of 5 spherical aberration profiles (-0.2 to +0.2 μm). Contrast sensitivity over the range of spherical aberration was fitted with a polynomial function. Results: Three subjects (age 21 to 24 years) participated. The measured total mean spherical aberration resulting from the spherical aberration profiles produced by the deformable mirror was between -0.15 μm and +0.25 μm. The peak contrast sensitivity of this function for the 3 subjects combined occurred at +0.06 μm of spherical aberration. The peak contrast sensitivity was also achieved with positive spherical aberration for each subject's data fitted individually (mean 0.09). Conclusion: There was intersubject variability in the measurements; however, the mean visual performance was best with the introduction of a small positive spherical aberration.

Original languageEnglish (US)
Pages (from-to)1229-1233
Number of pages5
JournalJournal of Cataract and Refractive Surgery
Issue number7
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery


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