Spermatozoal response to osmotic stress

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


The process of sperm cryopreservation imparts on sperm cells the stress of low-temperature and drastic osmotic change. Damage to the cell plasma membrane results in cell injury in a number of cellular structures and associated functions. Studies in the author's laboratory have focused upon the various mechanisms of osmotic and thermal injury including plasma membrane lipid structure, mitochondrial membrane potential, and intracellular signaling. We have determined that cryoinjury to sperm, as for somatic cells, is a multi-factorial event and some of these events are reversible while some are not.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalAnimal Reproduction Science
Issue number1-4 SPEC. ISS.
StatePublished - Oct 2005


  • Cell signaling
  • Cryopreservation
  • Osmotic tolerance
  • Sperm

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Genetics
  • Food Animals
  • Endocrinology


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