Sperm mitochondrial regulation in motility and fertility in horses

Stuart A Meyers, Evelyn Bulkeley, Azarene Foutouhi

Research output: Contribution to journalReview article

Abstract

The biological nature of age-related declines in fertility in males of any species, including stallions, has been elusive. In horses, the economic costs to the breeding industry are frequently extensive. Mitochondrial function in ejaculated sperm, which is essential for sperm motility, is reflected by adenosine triphosphate production, mitochondrial oxidative efficiency and production of reactive oxygen species, and that this balance may become compromised in ageing stallions and during the process of cryopreservation. This presentation will focus on mitochondrial integrity and function as an avenue for understanding the pathophysiology of sperm when undergoing cryopreservation and male ageing. We discuss the importance of understanding the differences and similarities of sperm mitochondria to that of somatic cells regarding structure and mitochondrial biochemistry relating to sperm function. The roles of oxidative phosphorylation and glycolysis in sperm mitochondria are outlined as is the method of determining oxygen consumption and calcium homoeostasis in sperm mitochondria. Further, we outline the role of oxidative stress and reactive oxygen species.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalReproduction in domestic animals = Zuchthygiene
Volume54
DOIs
StatePublished - Sep 1 2019

Fingerprint

Horses
Fertility
Spermatozoa
spermatozoa
horses
Mitochondria
mitochondria
Cryopreservation
stallions
cryopreservation
reactive oxygen species
Reactive Oxygen Species
economic costs
adenosine triphosphate
oxidative phosphorylation
Sperm Motility
cell structures
Oxidative Phosphorylation
male fertility
glycolysis

Keywords

  • mitochondrial function
  • oxidative phosphorylation
  • reactive oxygen species
  • sperm

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Endocrinology

Cite this

Sperm mitochondrial regulation in motility and fertility in horses. / Meyers, Stuart A; Bulkeley, Evelyn; Foutouhi, Azarene.

In: Reproduction in domestic animals = Zuchthygiene, Vol. 54, 01.09.2019, p. 22-28.

Research output: Contribution to journalReview article

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