Spectroscopic monitoring of kidney tissue ischemic injury

Jason T. Fitzgerald, Andromachi P. Michalopoulou, Christoph Troppmann, Stavros G. Demos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to assess the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsR.R. Alfano, A. Katz
Pages25-29
Number of pages5
Volume5
Edition15
DOIs
StatePublished - 2004
EventOptical Biopsy V - San Jose, CA, United States
Duration: Jan 27 2004Jan 28 2004

Other

OtherOptical Biopsy V
CountryUnited States
CitySan Jose, CA
Period1/27/041/28/04

Keywords

  • Kidney
  • Laser spectroscopy
  • Spectroscopy tissue diagnostic
  • Tissue injury

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Fitzgerald, J. T., Michalopoulou, A. P., Troppmann, C., & Demos, S. G. (2004). Spectroscopic monitoring of kidney tissue ischemic injury. In R. R. Alfano, & A. Katz (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (15 ed., Vol. 5, pp. 25-29). [11] https://doi.org/10.1117/12.529284