Spectroscopic monitoring of kidney tissue ischemic injury

Jason T. Fitzgerald; Andromachi P. Michalopoulou; Christoph Troppmann; Stavros G. Demos

doi:10.1117/12.529284

Spectroscopic monitoring of kidney tissue ischemic injury

Jason T. Fitzgerald, Andromachi P. Michalopoulou, Christoph Troppmann, Stavros G. Demos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to assess the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	R.R. Alfano, A. Katz
Pages	25-29
Number of pages	5
Volume	5
Edition	15
DOIs	https://doi.org/10.1117/12.529284
State	Published - 2004
Event	Optical Biopsy V - San Jose, CA, United States Duration: Jan 27 2004 → Jan 28 2004

Other

Other	Optical Biopsy V
Country	United States
City	San Jose, CA
Period	1/27/04 → 1/28/04

Keywords

Kidney
Laser spectroscopy
Spectroscopy tissue diagnostic
Tissue injury

ASJC Scopus subject areas

Engineering(all)

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10.1117/12.529284

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Fitzgerald, J. T., Michalopoulou, A. P., Troppmann, C., & Demos, S. G. (2004). Spectroscopic monitoring of kidney tissue ischemic injury. In R. R. Alfano, & A. Katz (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (15 ed., Vol. 5, pp. 25-29). [11] https://doi.org/10.1117/12.529284

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title = "Spectroscopic monitoring of kidney tissue ischemic injury",

abstract = "Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to assess the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.",

keywords = "Kidney, Laser spectroscopy, Spectroscopy tissue diagnostic, Tissue injury",

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AU - Michalopoulou, Andromachi P.

AU - Troppmann, Christoph

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N2 - Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to assess the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

AB - Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to assess the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

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KW - Laser spectroscopy

KW - Spectroscopy tissue diagnostic

KW - Tissue injury

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