Spectroscopic detection of bladder cancer using near-infrared imaging techniques

Stavros G. Demos, Regina F Gandour-Edwards, Rajen Ramsamooj, Ralph W deVere White

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


High-contrast imaging of bladder cancer, is demonstrated using near-infrared autofluorescence under long-wavelength laser excitation in combination with cross-polarized elastic light scattering. Fresh unprocessed surgical specimens obtained following cystectomy or transurethral resection were utilized and a set of images for each tissue sample was recorded. These images were compared with the histopathology of the tissue sample. The experimental results indicate that the intensity of the near-infrared emission as well as that of the cross-polarized backscattered light was considerably different in cancer tissues than in that of the contiguous nonneoplastic tissues, allowing an accurate delineation of a tumor's margins.

Original languageEnglish (US)
Pages (from-to)767-771
Number of pages5
JournalJournal of Biomedical Optics
Issue number4
StatePublished - Jul 2004


  • Autofluorescence
  • Bladder cancer
  • Near-infrared
  • Polarization
  • Scattering

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials


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