Abstract
High-contrast imaging of bladder cancer, is demonstrated using near-infrared autofluorescence under long-wavelength laser excitation in combination with cross-polarized elastic light scattering. Fresh unprocessed surgical specimens obtained following cystectomy or transurethral resection were utilized and a set of images for each tissue sample was recorded. These images were compared with the histopathology of the tissue sample. The experimental results indicate that the intensity of the near-infrared emission as well as that of the cross-polarized backscattered light was considerably different in cancer tissues than in that of the contiguous nonneoplastic tissues, allowing an accurate delineation of a tumor's margins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 767-771 |
| Number of pages | 5 |
| Journal | Journal of Biomedical Optics |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2004 |
Keywords
- Autofluorescence
- Bladder cancer
- Near-infrared
- Polarization
- Scattering
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
- Clinical Biochemistry
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
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Cite this
Demos, S. G., Gandour-Edwards, R. F., Ramsamooj, R., & deVere White, R. W. (2004). Spectroscopic detection of bladder cancer using near-infrared imaging techniques. Journal of Biomedical Optics, 9(4), 767-771. https://doi.org/10.1117/1.1753587