Spectral imaging in preclinical research and clinical pathology

Richard M Levenson, Joseph Beechem, George McNamara

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, pre-clinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level. These tools can provide valuable insights into the basic mechanisms of life, and yield diagnostic and prognostic information for clinical applications. There are many multispectral technologies available, each with its own advantages and limitations. This chapter will present an overview of the rationale for spectral imaging, and discuss the hardware, software and sample labeling strategies that can optimize its usefulness in clinical settings.

Original languageEnglish (US)
Pages (from-to)339-361
Number of pages23
JournalAnalytical Cellular Pathology
Volume35
Issue number5-6
DOIs
StatePublished - 2012

Fingerprint

Clinical Pathology
Software
Research Personnel
Technology
Research

Keywords

  • Image analysis
  • immunofluorescence
  • immunohistochemistry
  • machine-vision
  • multispectral imaging
  • oncology
  • pathology
  • personalized medicine
  • segmentation

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Spectral imaging in preclinical research and clinical pathology. / Levenson, Richard M; Beechem, Joseph; McNamara, George.

In: Analytical Cellular Pathology, Vol. 35, No. 5-6, 2012, p. 339-361.

Research output: Contribution to journalArticle

Levenson, Richard M ; Beechem, Joseph ; McNamara, George. / Spectral imaging in preclinical research and clinical pathology. In: Analytical Cellular Pathology. 2012 ; Vol. 35, No. 5-6. pp. 339-361.
@article{02f861c67d1f4310bc3b95c0ba4ce27e,
title = "Spectral imaging in preclinical research and clinical pathology",
abstract = "Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, pre-clinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level. These tools can provide valuable insights into the basic mechanisms of life, and yield diagnostic and prognostic information for clinical applications. There are many multispectral technologies available, each with its own advantages and limitations. This chapter will present an overview of the rationale for spectral imaging, and discuss the hardware, software and sample labeling strategies that can optimize its usefulness in clinical settings.",
keywords = "Image analysis, immunofluorescence, immunohistochemistry, machine-vision, multispectral imaging, oncology, pathology, personalized medicine, segmentation",
author = "Levenson, {Richard M} and Joseph Beechem and George McNamara",
year = "2012",
doi = "10.3233/ACP-2012-0062",
language = "English (US)",
volume = "35",
pages = "339--361",
journal = "Analytical Cellular Pathology",
issn = "2210-7177",
publisher = "IOS Press",
number = "5-6",

}

TY - JOUR

T1 - Spectral imaging in preclinical research and clinical pathology

AU - Levenson, Richard M

AU - Beechem, Joseph

AU - McNamara, George

PY - 2012

Y1 - 2012

N2 - Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, pre-clinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level. These tools can provide valuable insights into the basic mechanisms of life, and yield diagnostic and prognostic information for clinical applications. There are many multispectral technologies available, each with its own advantages and limitations. This chapter will present an overview of the rationale for spectral imaging, and discuss the hardware, software and sample labeling strategies that can optimize its usefulness in clinical settings.

AB - Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, pre-clinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level. These tools can provide valuable insights into the basic mechanisms of life, and yield diagnostic and prognostic information for clinical applications. There are many multispectral technologies available, each with its own advantages and limitations. This chapter will present an overview of the rationale for spectral imaging, and discuss the hardware, software and sample labeling strategies that can optimize its usefulness in clinical settings.

KW - Image analysis

KW - immunofluorescence

KW - immunohistochemistry

KW - machine-vision

KW - multispectral imaging

KW - oncology

KW - pathology

KW - personalized medicine

KW - segmentation

UR - http://www.scopus.com/inward/record.url?scp=84870857273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870857273&partnerID=8YFLogxK

U2 - 10.3233/ACP-2012-0062

DO - 10.3233/ACP-2012-0062

M3 - Article

C2 - 22475632

AN - SCOPUS:84870857273

VL - 35

SP - 339

EP - 361

JO - Analytical Cellular Pathology

JF - Analytical Cellular Pathology

SN - 2210-7177

IS - 5-6

ER -