Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis

Craig Watson, Fernando Cendes, Darren Fuerst, Francois Dubeau, Bill Williamson, Allan Evans, Frederick Andermann

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Magnetic resonance imaging (MRI)-based volumetric measurements of the hippocampal formation are useful in detecting unilateral hippocampal sclerosis (HS) in patients with temporal lobe epilepsy. In this pathologic entity, volumetric MRI analysis shows the epileptogenic structure to be atrophic when compared with the normal, nonepileptogenic side. Some authors have suggested that the radiological features of atrophy of medial temporal lobe structures are common in patients with complex partial seizures, but also are seen frequently in other seizure types and can occur even in patients without epilepsy. Objective: To determine if seizures originating in extrahippocampal sites cause gliosis, cell loss, and atrophy of medial temporal lobe structures (ie, HS). Methods: We studied 110 patients with chronic epilepsy using volumetric MRI measurements of the hippocampal formation. Seventeen patients had pathologically proven HS, 27 patients had seizures due to extratemporal structural lesions, 15 patients had seizures caused by extrahippocampal temporal lobe lesions, 29 patients had primary generalized epilepsy, and 22 patients had secondary generalized epilepsy. Results: All 17 patients with HS showed significantly reduced absolute hippocampal formation volumes of greater than 2 SDs below the mean of the control groups. The preoperative hippocampal formation volume measurements correlated well with the severity of HS on pathological examination. Hippocampal volumes were within the normal range in all patients with primary generalized epilepsy, secondary generalized epilepsy, extratemporal structural lesions, and extrahippocampal temporal lobe lesions. Conclusions: Seizures originating at extrahippocampal sites do not cause gliosis, cell loss, or atrophy of medial temporal structures. Significant reduction in hippocampal volumes is a specific marker for HS.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalArchives of Neurology
Volume54
Issue number1
StatePublished - 1997
Externally publishedYes

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Sclerosis
Magnetic Resonance Imaging
Generalized Epilepsy
Seizures
Temporal Lobe
Hippocampus
Atrophy
Gliosis
Epilepsy
Specificity
Temporal Lobe Epilepsy
Reference Values
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Watson, C., Cendes, F., Fuerst, D., Dubeau, F., Williamson, B., Evans, A., & Andermann, F. (1997). Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis. Archives of Neurology, 54(1), 67-73.

Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis. / Watson, Craig; Cendes, Fernando; Fuerst, Darren; Dubeau, Francois; Williamson, Bill; Evans, Allan; Andermann, Frederick.

In: Archives of Neurology, Vol. 54, No. 1, 1997, p. 67-73.

Research output: Contribution to journalArticle

Watson, C, Cendes, F, Fuerst, D, Dubeau, F, Williamson, B, Evans, A & Andermann, F 1997, 'Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis', Archives of Neurology, vol. 54, no. 1, pp. 67-73.
Watson C, Cendes F, Fuerst D, Dubeau F, Williamson B, Evans A et al. Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis. Archives of Neurology. 1997;54(1):67-73.
Watson, Craig ; Cendes, Fernando ; Fuerst, Darren ; Dubeau, Francois ; Williamson, Bill ; Evans, Allan ; Andermann, Frederick. / Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis. In: Archives of Neurology. 1997 ; Vol. 54, No. 1. pp. 67-73.
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