Specific pathogen free macaque colonies: A review of principles and recent advances for viral testing and colony management

Joann L. Yee, Thomas H. Vanderford, Elizabeth S. Didier, Stanton Gray, Anne Lewis, Jeffrey A Roberts, Kerry Taylor, Rudolf P. Bohm

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.

Original languageEnglish (US)
Pages (from-to)55-78
Number of pages24
JournalJournal of Medical Primatology
Volume45
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • Herpes B virus
  • Macaque colony management
  • Simian betaretrovirus
  • Simian immunodeficiency virus
  • Simian T-cell lymphotropic virus
  • Specific pathogen free
  • Virus testing

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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