Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome

Joel P. Bish, Akshay Pendyal, Lijun Ding, Heather Ferrante, Vy Nguyen, Donna McDonald-McGinn, Elaine Zackai, Tony J Simon

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37 Scopus citations

Abstract

Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalNeuroscience Letters
Volume399
Issue number3
DOIs
StatePublished - May 22 2006

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Keywords

  • Cerebellum
  • Chromosome 22q11.2
  • Psychopathology
  • VCFS
  • Visuospatial

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bish, J. P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D., Zackai, E., & Simon, T. J. (2006). Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters, 399(3), 245-248. https://doi.org/10.1016/j.neulet.2006.02.001