Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome

Joel P. Bish, Akshay Pendyal, Lijun Ding, Heather Ferrante, Vy Nguyen, Donna McDonald-McGinn, Elaine Zackai, Tony J Simon

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalNeuroscience Letters
Volume399
Issue number3
DOIs
StatePublished - May 22 2006

Fingerprint

DiGeorge Syndrome
Chromosome Deletion
Cerebellum
Psychopathology
Brain
Incidence
Cognitive Dysfunction

Keywords

  • Cerebellum
  • Chromosome 22q11.2
  • Psychopathology
  • VCFS
  • Visuospatial

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bish, J. P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D., ... Simon, T. J. (2006). Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters, 399(3), 245-248. https://doi.org/10.1016/j.neulet.2006.02.001

Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. / Bish, Joel P.; Pendyal, Akshay; Ding, Lijun; Ferrante, Heather; Nguyen, Vy; McDonald-McGinn, Donna; Zackai, Elaine; Simon, Tony J.

In: Neuroscience Letters, Vol. 399, No. 3, 22.05.2006, p. 245-248.

Research output: Contribution to journalArticle

Bish, JP, Pendyal, A, Ding, L, Ferrante, H, Nguyen, V, McDonald-McGinn, D, Zackai, E & Simon, TJ 2006, 'Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome', Neuroscience Letters, vol. 399, no. 3, pp. 245-248. https://doi.org/10.1016/j.neulet.2006.02.001
Bish JP, Pendyal A, Ding L, Ferrante H, Nguyen V, McDonald-McGinn D et al. Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters. 2006 May 22;399(3):245-248. https://doi.org/10.1016/j.neulet.2006.02.001
Bish, Joel P. ; Pendyal, Akshay ; Ding, Lijun ; Ferrante, Heather ; Nguyen, Vy ; McDonald-McGinn, Donna ; Zackai, Elaine ; Simon, Tony J. / Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. In: Neuroscience Letters. 2006 ; Vol. 399, No. 3. pp. 245-248.
@article{dc305210de204aef9ba19d1e465afc01,
title = "Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome",
abstract = "Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group.",
keywords = "Cerebellum, Chromosome 22q11.2, Psychopathology, VCFS, Visuospatial",
author = "Bish, {Joel P.} and Akshay Pendyal and Lijun Ding and Heather Ferrante and Vy Nguyen and Donna McDonald-McGinn and Elaine Zackai and Simon, {Tony J}",
year = "2006",
month = "5",
day = "22",
doi = "10.1016/j.neulet.2006.02.001",
language = "English (US)",
volume = "399",
pages = "245--248",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome

AU - Bish, Joel P.

AU - Pendyal, Akshay

AU - Ding, Lijun

AU - Ferrante, Heather

AU - Nguyen, Vy

AU - McDonald-McGinn, Donna

AU - Zackai, Elaine

AU - Simon, Tony J

PY - 2006/5/22

Y1 - 2006/5/22

N2 - Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group.

AB - Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group.

KW - Cerebellum

KW - Chromosome 22q11.2

KW - Psychopathology

KW - VCFS

KW - Visuospatial

UR - http://www.scopus.com/inward/record.url?scp=33646131176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646131176&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2006.02.001

DO - 10.1016/j.neulet.2006.02.001

M3 - Article

C2 - 16517069

AN - SCOPUS:33646131176

VL - 399

SP - 245

EP - 248

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -