Abstract
Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.
Original language | English (US) |
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Pages (from-to) | 659-670 |
Number of pages | 12 |
Journal | Immunology and Allergy Clinics of North America |
Volume | 35 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2015 |
Externally published | Yes |
Keywords
- Immunoglobulin replacement
- Pneumococcal polysaccharide vaccine
- Recurrent sinopulmonary infections
- Specific antibody deficiency
- Vaccine failure
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology