Specific Antibody Deficiencies

Luke A. Wall; Victoria Dimitriades; Ricardo U. Sorensen

doi:10.1016/j.iac.2015.07.003

Specific Antibody Deficiencies

Luke A. Wall, Victoria Dimitriades, Ricardo U. Sorensen

Research output: Contribution to journal › Review article

15 Scopus citations

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Original language	English (US)
Pages (from-to)	659-670
Number of pages	12
Journal	Immunology and Allergy Clinics of North America
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.iac.2015.07.003
State	Published - Nov 1 2015
Externally published	Yes

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Keywords

Immunoglobulin replacement
Pneumococcal polysaccharide vaccine
Recurrent sinopulmonary infections
Specific antibody deficiency
Vaccine failure

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

Wall, L. A., Dimitriades, V., & Sorensen, R. U. (2015). Specific Antibody Deficiencies. Immunology and Allergy Clinics of North America, 35(4), 659-670. https://doi.org/10.1016/j.iac.2015.07.003

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Access to Document

10.1016/j.iac.2015.07.003