Specific Antibody Deficiencies

Luke A. Wall, Victoria Dimitriades, Ricardo U. Sorensen

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Original languageEnglish (US)
Pages (from-to)659-670
Number of pages12
JournalImmunology and Allergy Clinics of North America
Volume35
Issue number4
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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Antibodies
Polysaccharides
Pneumococcal Vaccines
Immunity
Vaccines
Phenotype
Antigens
Infection
Population
Therapeutics

Keywords

  • Immunoglobulin replacement
  • Pneumococcal polysaccharide vaccine
  • Recurrent sinopulmonary infections
  • Specific antibody deficiency
  • Vaccine failure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Specific Antibody Deficiencies. / Wall, Luke A.; Dimitriades, Victoria; Sorensen, Ricardo U.

In: Immunology and Allergy Clinics of North America, Vol. 35, No. 4, 01.11.2015, p. 659-670.

Research output: Contribution to journalReview article

Wall, Luke A. ; Dimitriades, Victoria ; Sorensen, Ricardo U. / Specific Antibody Deficiencies. In: Immunology and Allergy Clinics of North America. 2015 ; Vol. 35, No. 4. pp. 659-670.
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