Specific Antibody Deficiencies

Luke A. Wall, Victoria Dimitriades, Ricardo U. Sorensen

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Original languageEnglish (US)
Pages (from-to)659-670
Number of pages12
JournalImmunology and Allergy Clinics of North America
Issue number4
StatePublished - Nov 1 2015
Externally publishedYes


  • Immunoglobulin replacement
  • Pneumococcal polysaccharide vaccine
  • Recurrent sinopulmonary infections
  • Specific antibody deficiency
  • Vaccine failure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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