Specific Antibody Deficiencies

Luke A. Wall; Victoria Dimitriades; Ricardo U. Sorensen

doi:10.1016/j.iac.2015.07.003

Specific Antibody Deficiencies

Luke A. Wall, Victoria Dimitriades, Ricardo U. Sorensen

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Original language	English (US)
Pages (from-to)	659-670
Number of pages	12
Journal	Immunology and Allergy Clinics of North America
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.iac.2015.07.003
State	Published - Nov 1 2015
Externally published	Yes

Keywords

Immunoglobulin replacement
Pneumococcal polysaccharide vaccine
Recurrent sinopulmonary infections
Specific antibody deficiency
Vaccine failure

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.iac.2015.07.003

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title = "Specific Antibody Deficiencies",

abstract = "Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.",

keywords = "Immunoglobulin replacement, Pneumococcal polysaccharide vaccine, Recurrent sinopulmonary infections, Specific antibody deficiency, Vaccine failure",

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AU - Wall, Luke A.

AU - Dimitriades, Victoria

AU - Sorensen, Ricardo U.

PY - 2015/11/1

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N2 - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

AB - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

KW - Immunoglobulin replacement

KW - Pneumococcal polysaccharide vaccine

KW - Recurrent sinopulmonary infections

KW - Specific antibody deficiency

KW - Vaccine failure

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ER -

Specific Antibody Deficiencies

Abstract

Keywords

ASJC Scopus subject areas

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