Abstract
Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 659-670 |
| Number of pages | 12 |
| Journal | Immunology and Allergy Clinics of North America |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 1 2015 |
| Externally published | Yes |
Fingerprint
Keywords
- Immunoglobulin replacement
- Pneumococcal polysaccharide vaccine
- Recurrent sinopulmonary infections
- Specific antibody deficiency
- Vaccine failure
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Specific Antibody Deficiencies. / Wall, Luke A.; Dimitriades, Victoria; Sorensen, Ricardo U.
In: Immunology and Allergy Clinics of North America, Vol. 35, No. 4, 01.11.2015, p. 659-670.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Specific Antibody Deficiencies
AU - Wall, Luke A.
AU - Dimitriades, Victoria
AU - Sorensen, Ricardo U.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.
AB - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.
KW - Immunoglobulin replacement
KW - Pneumococcal polysaccharide vaccine
KW - Recurrent sinopulmonary infections
KW - Specific antibody deficiency
KW - Vaccine failure
UR - http://www.scopus.com/inward/record.url?scp=84943819663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943819663&partnerID=8YFLogxK
U2 - 10.1016/j.iac.2015.07.003
DO - 10.1016/j.iac.2015.07.003
M3 - Review article
C2 - 26454312
AN - SCOPUS:84943819663
VL - 35
SP - 659
EP - 670
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
SN - 0889-8561
IS - 4
ER -