Specific Antibody Deficiencies

Luke A. Wall; Victoria Dimitriades; Ricardo U. Sorensen

doi:10.1016/j.iac.2015.07.003

Specific Antibody Deficiencies

Luke A. Wall, Victoria Dimitriades, Ricardo U. Sorensen

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

Original language	English (US)
Pages (from-to)	659-670
Number of pages	12
Journal	Immunology and Allergy Clinics of North America
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.iac.2015.07.003
State	Published - Nov 1 2015
Externally published	Yes

Keywords

Immunoglobulin replacement
Pneumococcal polysaccharide vaccine
Recurrent sinopulmonary infections
Specific antibody deficiency
Vaccine failure

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.iac.2015.07.003

Cite this

@article{f0a73f1b887142df9726276934fd8531,

title = "Specific Antibody Deficiencies",

abstract = "Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.",

keywords = "Immunoglobulin replacement, Pneumococcal polysaccharide vaccine, Recurrent sinopulmonary infections, Specific antibody deficiency, Vaccine failure",

author = "Wall, {Luke A.} and Victoria Dimitriades and Sorensen, {Ricardo U.}",

year = "2015",

month = nov,

day = "1",

doi = "10.1016/j.iac.2015.07.003",

language = "English (US)",

volume = "35",

pages = "659--670",

journal = "Immunology and Allergy Clinics of North America",

issn = "0889-8561",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Specific Antibody Deficiencies

AU - Wall, Luke A.

AU - Dimitriades, Victoria

AU - Sorensen, Ricardo U.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

AB - Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

KW - Immunoglobulin replacement

KW - Pneumococcal polysaccharide vaccine

KW - Recurrent sinopulmonary infections

KW - Specific antibody deficiency

KW - Vaccine failure

UR - http://www.scopus.com/inward/record.url?scp=84943819663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943819663&partnerID=8YFLogxK

U2 - 10.1016/j.iac.2015.07.003

DO - 10.1016/j.iac.2015.07.003

M3 - Review article

C2 - 26454312

AN - SCOPUS:84943819663

VL - 35

SP - 659

EP - 670

JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

SN - 0889-8561

IS - 4

ER -

Specific Antibody Deficiencies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this