Specific and nonspecific NK cell activation during virus infection

Ayotunde O. Dokun, Sung Jin Kim, Hamish R C Smith, Hyun Seok P Kang, Dortha T. Chu, Wayne M. Yokoyama

Research output: Contribution to journalArticlepeer-review

365 Scopus citations


The natural killer (NK) cell activation receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV). We show here that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection. During a later phase of infection, however, Ly49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration. With vaccinia virus infection, neither the early nor late phase of NK cell proliferation was selective for Ly49H+ NK cells. These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo.

Original languageEnglish (US)
Pages (from-to)951-956
Number of pages6
JournalNature Immunology
Issue number10
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Specific and nonspecific NK cell activation during virus infection'. Together they form a unique fingerprint.

Cite this