Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

S. Dandekar, S. Sukumar, H. Zarbl, L. J. Young, R. D. Cardiff

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Abstract

Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

Original languageEnglish (US)
Pages (from-to)4104-4108
Number of pages5
JournalMolecular and Cellular Biology
Volume6
Issue number11
StatePublished - Nov 1986

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ras Genes
NIH 3T3 Cells
Breast Neoplasms
DNA
Codon
Adenosine
Transfection
Nucleotides
Radiation
Mutation

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. / Dandekar, S.; Sukumar, S.; Zarbl, H.; Young, L. J.; Cardiff, R. D.

In: Molecular and Cellular Biology, Vol. 6, No. 11, 11.1986, p. 4104-4108.

Research output: Contribution to journalArticle

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