Specifcity may be overrated in cancer immunotherapy: Getting to know the nonspecifc side of memory T cells

Gail D. Sckisel, William J Murphy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8+ T cells in cytokine-based cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)1208-1210
Number of pages3
JournalOncoImmunology
Volume1
Issue number7
DOIs
StatePublished - 2012

Keywords

  • Antigen non-specific T cells
  • Bystander CD8 T cells
  • Cancer immunotherapy
  • Cytokine induced killer cells
  • LAK cells
  • NKG2D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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