Species-specific, postentry barriers to primate immunodeficiency virus infection

Wolfgang Hofmann, David Schubert, Jason LaBonte, Linda Munson, Susan Gibson, Jonathan Scammell, Paul Ferrigno, Joseph Sodroski

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV(mac)), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIV(mac) and MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for the SIV(mac) vector compared with those of the HIV-1 vector. Prosimian cells were resistant to both HIV-1 and SIV(mac) vectors, although the MuLV vector was able to infect these cells. Cells from other mammalian species were roughly equivalent in susceptibility to the three vectors, with the exception of rabbit cells, which were specifically resistant to the HIV-1 vector. The level of HIV-1 vector expression was very low in transduced cells of rodent, rabbit, cow, and pig origin. Early postentry restriction of primate immunodeficiency virus infection exhibits patterns largely coincident with species borders and applies to diverse cell types within an individual host, suggesting the involvement of species-specific, widely expressed cellular factors.

Original languageEnglish (US)
Pages (from-to)10020-10028
Number of pages9
JournalJournal of Virology
Volume73
Issue number12
StatePublished - Dec 1999

Fingerprint

Primate Lentiviruses
immunosuppression
Virus Diseases
Primates
Human immunodeficiency virus 1
viruses
HIV-1
Murine leukemia virus
infection
Murine Leukemia Viruses
cells
Strepsirhini
rabbits
Platyrrhini
Cercopithecidae
Rabbits
Vesiculovirus
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Cebidae

ASJC Scopus subject areas

  • Immunology

Cite this

Hofmann, W., Schubert, D., LaBonte, J., Munson, L., Gibson, S., Scammell, J., ... Sodroski, J. (1999). Species-specific, postentry barriers to primate immunodeficiency virus infection. Journal of Virology, 73(12), 10020-10028.

Species-specific, postentry barriers to primate immunodeficiency virus infection. / Hofmann, Wolfgang; Schubert, David; LaBonte, Jason; Munson, Linda; Gibson, Susan; Scammell, Jonathan; Ferrigno, Paul; Sodroski, Joseph.

In: Journal of Virology, Vol. 73, No. 12, 12.1999, p. 10020-10028.

Research output: Contribution to journalArticle

Hofmann, W, Schubert, D, LaBonte, J, Munson, L, Gibson, S, Scammell, J, Ferrigno, P & Sodroski, J 1999, 'Species-specific, postentry barriers to primate immunodeficiency virus infection', Journal of Virology, vol. 73, no. 12, pp. 10020-10028.
Hofmann W, Schubert D, LaBonte J, Munson L, Gibson S, Scammell J et al. Species-specific, postentry barriers to primate immunodeficiency virus infection. Journal of Virology. 1999 Dec;73(12):10020-10028.
Hofmann, Wolfgang ; Schubert, David ; LaBonte, Jason ; Munson, Linda ; Gibson, Susan ; Scammell, Jonathan ; Ferrigno, Paul ; Sodroski, Joseph. / Species-specific, postentry barriers to primate immunodeficiency virus infection. In: Journal of Virology. 1999 ; Vol. 73, No. 12. pp. 10020-10028.
@article{1387e55c717d49b6bc06340a203b089d,
title = "Species-specific, postentry barriers to primate immunodeficiency virus infection",
abstract = "By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV(mac)), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIV(mac) and MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for the SIV(mac) vector compared with those of the HIV-1 vector. Prosimian cells were resistant to both HIV-1 and SIV(mac) vectors, although the MuLV vector was able to infect these cells. Cells from other mammalian species were roughly equivalent in susceptibility to the three vectors, with the exception of rabbit cells, which were specifically resistant to the HIV-1 vector. The level of HIV-1 vector expression was very low in transduced cells of rodent, rabbit, cow, and pig origin. Early postentry restriction of primate immunodeficiency virus infection exhibits patterns largely coincident with species borders and applies to diverse cell types within an individual host, suggesting the involvement of species-specific, widely expressed cellular factors.",
author = "Wolfgang Hofmann and David Schubert and Jason LaBonte and Linda Munson and Susan Gibson and Jonathan Scammell and Paul Ferrigno and Joseph Sodroski",
year = "1999",
month = "12",
language = "English (US)",
volume = "73",
pages = "10020--10028",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "12",

}

TY - JOUR

T1 - Species-specific, postentry barriers to primate immunodeficiency virus infection

AU - Hofmann, Wolfgang

AU - Schubert, David

AU - LaBonte, Jason

AU - Munson, Linda

AU - Gibson, Susan

AU - Scammell, Jonathan

AU - Ferrigno, Paul

AU - Sodroski, Joseph

PY - 1999/12

Y1 - 1999/12

N2 - By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV(mac)), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIV(mac) and MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for the SIV(mac) vector compared with those of the HIV-1 vector. Prosimian cells were resistant to both HIV-1 and SIV(mac) vectors, although the MuLV vector was able to infect these cells. Cells from other mammalian species were roughly equivalent in susceptibility to the three vectors, with the exception of rabbit cells, which were specifically resistant to the HIV-1 vector. The level of HIV-1 vector expression was very low in transduced cells of rodent, rabbit, cow, and pig origin. Early postentry restriction of primate immunodeficiency virus infection exhibits patterns largely coincident with species borders and applies to diverse cell types within an individual host, suggesting the involvement of species-specific, widely expressed cellular factors.

AB - By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV(mac)), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIV(mac) and MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for the SIV(mac) vector compared with those of the HIV-1 vector. Prosimian cells were resistant to both HIV-1 and SIV(mac) vectors, although the MuLV vector was able to infect these cells. Cells from other mammalian species were roughly equivalent in susceptibility to the three vectors, with the exception of rabbit cells, which were specifically resistant to the HIV-1 vector. The level of HIV-1 vector expression was very low in transduced cells of rodent, rabbit, cow, and pig origin. Early postentry restriction of primate immunodeficiency virus infection exhibits patterns largely coincident with species borders and applies to diverse cell types within an individual host, suggesting the involvement of species-specific, widely expressed cellular factors.

UR - http://www.scopus.com/inward/record.url?scp=0032708384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032708384&partnerID=8YFLogxK

M3 - Article

VL - 73

SP - 10020

EP - 10028

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 12

ER -