Spatiotemporal integration of developmental cues in neural development

Laura N Borodinsky, Yesser H. Belgacem, Immani Swapna, Olesya Visina, Olga A. Balashova, Eduardo B. Sequerra, Michelle K. Tu, Jacqueline B. Levin, Kira A. Spencer, Patricio A. Castro, Andrew M. Hamilton, Sangwoo Shim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms of three classes of these cues: morphogenetic proteins, electrical activity, and the environment. We focus on second messenger dynamics and their role as integrators of the action of diverse cues, enabling plasticity in the process of neural development.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalDevelopmental Neurobiology
Issue number4
StatePublished - Apr 1 2015


  • Calcium
  • Electrical activity
  • Environmental factors
  • Morphogenetic proteins
  • Neuronal differentiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience


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