Spatiotemporal integration of developmental cues in neural development

Laura N Borodinsky, Yesser H. Belgacem, Immani Swapna, Olesya Visina, Olga A. Balashova, Eduardo B. Sequerra, Michelle K. Tu, Jacqueline B. Levin, Kira A. Spencer, Patricio A. Castro, Andrew M. Hamilton, Sangwoo Shim

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms of three classes of these cues: morphogenetic proteins, electrical activity, and the environment. We focus on second messenger dynamics and their role as integrators of the action of diverse cues, enabling plasticity in the process of neural development.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalDevelopmental Neurobiology
Volume75
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Calcium
  • Electrical activity
  • Environmental factors
  • Morphogenetic proteins
  • Neuronal differentiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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  • Cite this

    Borodinsky, L. N., Belgacem, Y. H., Swapna, I., Visina, O., Balashova, O. A., Sequerra, E. B., Tu, M. K., Levin, J. B., Spencer, K. A., Castro, P. A., Hamilton, A. M., & Shim, S. (2015). Spatiotemporal integration of developmental cues in neural development. Developmental Neurobiology, 75(4), 349-359. https://doi.org/10.1002/dneu.22254