Spatiotemporal Dynamics of Word Processing in the Human Brain

Ryan T. Canolty, Maryam Soltani, Sarang S. Dalal, Erik Edwards, Nina F. Dronkers, Srikantan S. Nagarajan, Heidi E. Kirsch, Nicholas M. Barbaro, Robert T. Knight

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

We examined the spatiotemporal dynamics of word processing by recording the electrocorticogram (ECoG) from the lateral frontotemporal cortex of neurosurgical patients chronically implanted with subdural electrode grids. Subjects engaged in a target detection task where proper names served as infrequent targets embedded in a stream of task-irrelevant verbs and nonwords. Verbs described actions related to the hand (e.g, throw) or mouth (e.g., blow), while unintelligible nonwords were sounds which matched the verbs in duration, intensity, temporal modulation, and power spectrum. Complex oscillatory dynamics were observed in the delta, theta, alpha, beta, low, and high gamma (HG) bands in response to presentation of all stimulus types. HG activity (80–200 Hz) in the ECoG tracked the spatiotemporal dynamics of word processing and identified a network of cortical structures involved in early word processing. HG was used to determine the relative onset, peak, and offset times of local cortical activation during word processing. Listening to verbs compared to nonwords sequentially activates first the posterior superior temporal gyrus (post-STG), then the middle superior temporal gyrus (mid-STG), followed by the superior temporal sulcus (STS). We also observed strong phase-locking between pairs of electrodes in the theta band, with weaker phase-locking occurring in the delta, alpha, and beta frequency ranges. These results provide details on the first few hundred milliseconds of the spatiotemporal evolution of cortical activity during word processing and provide evidence consistent with the hypothesis that an oscillatory hierarchy coordinates the flow of information between distinct cortical regions during goal-directed behavior.

Original languageEnglish (US)
Pages (from-to)185-196
Number of pages12
JournalFrontiers in Neuroscience
Volume1
Issue number1
DOIs
StatePublished - Oct 15 2007

Keywords

  • electrocorticogram
  • gamma
  • oscillations
  • superior temporal gyrus
  • superior temporal sulcus
  • target detection
  • verbs
  • word processing

ASJC Scopus subject areas

  • Neuroscience(all)

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