Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae

Yoosook Lee, Clare D. Marsden, Laura C. Norris, Travis C. Collier, Bradley Main, Abdrahamane Fofana, Anthony J. Cornel, Gregory C Lanzaro

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The M and S forms of Anopheles gambiae have been the focus of intense study by malaria researchers and evolutionary biologists interested in ecological speciation. Divergence occurs at three discrete islands in genomes that are otherwise nearly identical. An "islands of speciation" model proposes that diverged regions contain genes that are maintained by selection in the face of gene flow. An alternative "incidental island" model maintains that gene flow between M and S is effectively zero and that divergence islands are unrelated to speciation. A "divergence island SNP" assay was used to explore the spatial and temporal distributions of hybrid genotypes. Results revealed that hybrid individuals occur at frequencies ranging between 5% and 97% in every population examined. A temporal analysis revealed that assortative mating is unstable and periodically breaks down, resulting in extensive hybridization. Results suggest that hybrids suffer a fitness disadvantage, but at least some hybrid genotypes are viable. Stable introgression of the 2L speciation island occurred at one site following a hybridization event.

Original languageEnglish (US)
Pages (from-to)19854-19859
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number49
DOIs
StatePublished - Dec 3 2013

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Anopheles gambiae
Gene Flow
Culicidae
Islands
Malaria
Genotype
Single Nucleotide Polymorphism
Research Personnel
Genome
Population
Genes

Keywords

  • Anopheles coluzzii
  • Population structure
  • Reproductive isolation

ASJC Scopus subject areas

  • General

Cite this

Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae. / Lee, Yoosook; Marsden, Clare D.; Norris, Laura C.; Collier, Travis C.; Main, Bradley; Fofana, Abdrahamane; Cornel, Anthony J.; Lanzaro, Gregory C.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 49, 03.12.2013, p. 19854-19859.

Research output: Contribution to journalArticle

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