Spatially localized hippocampal shape analysis in late-life cognitive decline

Jing Xie, Dan Alcantara, Nina Amenta, Evan Fletcher, Oliver Martinez, Maria Persianinova, Charles DeCarli, Owen Carmichael

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We present a method for generating data-driven, concise, and spatially localized parameterizations of hippocampal (HP) shape, and use the method to analyze HP atrophy in late-life cognitive decline. The method optimizes a set of shape basis vectors (shape components) that strike a balance between spatial locality and compact representation of population shape characteristics. The method can be used for exploratory analysis of localized shape deformations in any population of HP on which point-to-point correspondence mappings have been established via anatomical landmarking or high-dimensional warping. Experiments combine the method with an automated HP to HP mapping method to analyze tracings of 101 elderly subjects with normal cognition, mild cognitive impairment, and Alzheimer's Disease (AD) from an AD Center population. Results suggest that shape components corresponding to atrophy to the CA1 and subiculum HP fields - where early AD pathology is located - correlate strongly with robust measures of the cognitive dysfunction that is typical of early AD. Furthermore, the energy function minimized by the shape component optimization technique is shown to be smooth with few local minima, suggesting that the method may be relatively easy to apply in practice.

Original languageEnglish (US)
Pages (from-to)526-532
Number of pages7
JournalHippocampus
Volume19
Issue number6
DOIs
StatePublished - Jun 2009

Fingerprint

Alzheimer Disease
Atrophy
Population Characteristics
Cognitive Dysfunction
Cognition
Population
Hippocampus
Pathology

Keywords

  • Alzheimer's disease (AD)
  • CA1
  • Magnetic resonance imaging
  • Shape analysis
  • Subiculum

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Xie, J., Alcantara, D., Amenta, N., Fletcher, E., Martinez, O., Persianinova, M., ... Carmichael, O. (2009). Spatially localized hippocampal shape analysis in late-life cognitive decline. Hippocampus, 19(6), 526-532. https://doi.org/10.1002/hipo.20618

Spatially localized hippocampal shape analysis in late-life cognitive decline. / Xie, Jing; Alcantara, Dan; Amenta, Nina; Fletcher, Evan; Martinez, Oliver; Persianinova, Maria; DeCarli, Charles; Carmichael, Owen.

In: Hippocampus, Vol. 19, No. 6, 06.2009, p. 526-532.

Research output: Contribution to journalArticle

Xie, J, Alcantara, D, Amenta, N, Fletcher, E, Martinez, O, Persianinova, M, DeCarli, C & Carmichael, O 2009, 'Spatially localized hippocampal shape analysis in late-life cognitive decline', Hippocampus, vol. 19, no. 6, pp. 526-532. https://doi.org/10.1002/hipo.20618
Xie J, Alcantara D, Amenta N, Fletcher E, Martinez O, Persianinova M et al. Spatially localized hippocampal shape analysis in late-life cognitive decline. Hippocampus. 2009 Jun;19(6):526-532. https://doi.org/10.1002/hipo.20618
Xie, Jing ; Alcantara, Dan ; Amenta, Nina ; Fletcher, Evan ; Martinez, Oliver ; Persianinova, Maria ; DeCarli, Charles ; Carmichael, Owen. / Spatially localized hippocampal shape analysis in late-life cognitive decline. In: Hippocampus. 2009 ; Vol. 19, No. 6. pp. 526-532.
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