Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis

Aditi Guha, Cory Wyatt, Dimitrios C. Karampinos, Lorenzo Nardo, Thomas M. Link, Sharmila Majumdar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To evaluate a pulse sequence combining stimulated echo diffusion preparation with a 3D segmented spoiled gradient echo (SPGR) acquisition for diffusion tensor imaging (DTI) of knee cartilage in healthy and osteoarthritis (OA) populations for early diagnosis and characterization of OA. Methods: Diffusion-weighted images of 40 subjects (20 healthy, 20 OA) at baseline and 20 subjects (10 healthy, 10 OA) at one year were obtained. The subjects were classified according to Kellgren Lawrence (KL) and whole organ magnetic resonance imaging scoring (WORMS) method acquired at 3. T. Cartilage full thickness and laminar mean diffusivity (MD) and fractional anisotropy (FA) values were quantified. The reproducibility of MD and FA values was assessed in five healthy human subjects based on test-retest scans. Results: In general, the full thickness MD values were higher in subjects with knee OA compared to healthy controls in both the baseline and follow up cohort. Laminar analysis MD and FA results were significantly different (p<. 0.05) between the bone-articular and articular layer with the articular layer having higher MD and lower FA value compared to the bone layer. The global reproducibility error was 6.5% for MD and 11.6% for FA. Conclusion: The diffusion-weighted stimulated echo-based sequence may be used as a valuable tool for early diagnosis and characterization of knee OA at 3. T in the future.

Original languageEnglish (US)
Article number8392
Pages (from-to)1051-1058
Number of pages8
JournalMagnetic Resonance Imaging
Volume33
Issue number9
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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Knee Osteoarthritis
Anisotropy
Cartilage
Articular Cartilage
Magnetic resonance
Magnetic Resonance Spectroscopy
Osteoarthritis
Healthy Volunteers
Joints
Early Diagnosis
Bone and Bones
Diffusion Tensor Imaging
Bone
Knee
Research Design
Diffusion tensor imaging
Magnetic Resonance Imaging
Population
Imaging techniques

Keywords

  • 3T
  • Cartilage
  • Diffusion tensor imaging (DTI)
  • Laminar analysis
  • Osteoarthritis (OA)
  • Stimulated echo (STE) pulse sequence

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis. / Guha, Aditi; Wyatt, Cory; Karampinos, Dimitrios C.; Nardo, Lorenzo; Link, Thomas M.; Majumdar, Sharmila.

In: Magnetic Resonance Imaging, Vol. 33, No. 9, 8392, 01.11.2015, p. 1051-1058.

Research output: Contribution to journalArticle

Guha, Aditi ; Wyatt, Cory ; Karampinos, Dimitrios C. ; Nardo, Lorenzo ; Link, Thomas M. ; Majumdar, Sharmila. / Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis. In: Magnetic Resonance Imaging. 2015 ; Vol. 33, No. 9. pp. 1051-1058.
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