Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys

Pierre Lavenex, Pamela Banta Lavenex, David G Amaral

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The hippocampus is important for the acquisition of spatial representations of the environment and consequently in contextual memory. This suggests that the neural substrates underlying spatial cognition might be essential for remembering specific life episodes. Indeed, hippocampal lesions prevent spatial relational learning in adult rodents and monkeys, and result in profound amnesia in adult humans. In contrast, we show here that monkeys with neonatal hippocampal lesions learned new spatial relational information. Our experiments suggest that early hippocampal damage leads to functional brain reorganization that enables spatial information to be acquired through the use of brain regions that normally do not subserve this function.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalNature Neuroscience
Volume10
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys'. Together they form a unique fingerprint.

  • Cite this