Spatial Patterns of Persistent Neural Activity Vary with the Behavioral Context of Short-Term Memory

Kayvon Daie, Mark S Goldman, Emre R F Aksay

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A short-term memory can be evoked by different inputs and control separate targets in different behavioral contexts. To address the circuit mechanisms underlying context-dependent memory function, we determined through optical imaging how memory isencoded at the whole-network level in two behavioral settings. Persistent neural activity maintaining amemory of desired eye position was imaged throughout the oculomotor integrator after saccadic or optokinetic stimulation. While eye position was encoded by the amplitude of network activity, the spatial patterns of firing were context dependent: cells located caudally generally were most persistent following saccadic input, whereas cells located rostrally were most persistent following optokinetic input. To explain these data, we computationally identified four independent modes of network activity and found these were differentially accessed bysaccadic and optokinetic inputs. These results show how a circuit can simultaneously encode memory value and behavioral context, respectively, in its amplitude and spatial pattern of persistent firing.

Original languageEnglish (US)
Pages (from-to)847-860
Number of pages14
JournalNeuron
Volume85
Issue number4
DOIs
StatePublished - Feb 18 2015

ASJC Scopus subject areas

  • Neuroscience(all)

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