Spatial patterns and impacts of environmental and climatic factors on canine sinonasal aspergillosis in Northern California

Monise Magro, Jane E Sykes, Polina Vishkautsan, Beatriz Martinez Lopez

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sinonasal aspergillosis (SNA) causes chronic nasal discharge in dogs and has a worldwide distribution, although most reports of SNA in North America originate from the western USA. SNA is mainly caused by Aspergillus fumigatus, a ubiquitous saprophytic filamentous fungus. Infection is thought to follow inhalation of spores. SNA is a disease of the nasal cavity and/or sinuses with variable degrees of local invasion and destruction. While some host factors appear to predispose to SNA (such as belonging to a dolichocephalic breed), environmental risk factors have been scarcely studied. Because A. fumigatus is also the main cause of invasive aspergillosis in humans, unraveling the distribution and the environmental and climatic risk factors for this agent in dogs would be of great benefit for public health studies, advancing understanding of both distribution and risk factors in humans. In this study, we reviewed electronic medical records of 250 dogs diagnosed with SNA between 1990 and 2014 at the University of California Davis Veterinary Medical Teaching Hospital (VMTH). A 145-mile radius catchment area around the VMTH was selected. Data were aggregated by zip code and incorporated into a multivariate logistic regression model. The logistic regression model was compared to an autologistic regression model to evaluate the effect of spatial autocorrelation. Traffic density, active composting sites, and environmental and climatic factors related with wind and temperature were significantly associated with increase in disease occurrence in dogs. Results provide valuable information about the risk factors and spatial distribution of SNA in dogs in Northern California. Our ultimate goal is to utilize the results to investigate risk-based interventions, promote awareness, and serve as a model for further studies of aspergillosis in humans.

Original languageEnglish (US)
Article number104
JournalFrontiers in Veterinary Science
Volume4
Issue numberJUL
DOIs
StatePublished - Jul 3 2017

Fingerprint

Aspergillosis
aspergillosis
climatic factors
Canidae
environmental factors
dogs
Dogs
risk factors
Logistic Models
Aspergillus fumigatus
Teaching Hospitals
Spatial Analysis
disease occurrence
nasal cavity
Electronic Health Records
Paranasal Sinuses
Nasal Cavity
North America
sinuses
composting

Keywords

  • Aspergillus
  • Dogs
  • Epidemiology
  • Fungal infection
  • Public health
  • Risk map
  • Spatial analysis
  • Spores

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Spatial patterns and impacts of environmental and climatic factors on canine sinonasal aspergillosis in Northern California. / Magro, Monise; Sykes, Jane E; Vishkautsan, Polina; Martinez Lopez, Beatriz.

In: Frontiers in Veterinary Science, Vol. 4, No. JUL, 104, 03.07.2017.

Research output: Contribution to journalArticle

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