Spatial distribution of deoxymyoglobin in human muscle: An index of local tissue oxygenation

Tuan Khanh Tran, Napapon Sailasuta, Ralph Hurd, Thomas Jue

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The proximal histidyl N(δ)H signal of myoglobin is detectable in 1H NMR spectra of myocardial and skeletal muscle, and its intensity reflects the intracellular oxygenation. At 1.5 Tesla (T), the typical field strength of clinical magnetic resonance imaging (MRI) magnets, the paramagnetic relaxation contribution decreases sufficiently to permit the implementation of chemical shift imaging technique to map the spatial distribution of the deoxy Mb N(δ)H signal from human gastrocnemius muscle. One and two- dimensional chemical shift imaging experiments reveal clearly the localized deoxy Mb signal in muscle and consequently the spatial distribution of the cellular oxygenation. The results indicate the feasibility to assess the pO2 in tissue regions and to directly study the regulation of oxidative metabolism in human tissue.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalNMR in Biomedicine
Volume12
Issue number1
DOIs
StatePublished - Feb 1999

Fingerprint

Oxygenation
Spatial distribution
Muscle
Magnetic Resonance Imaging
Tissue
Muscles
Skeletal Muscle
Imaging techniques
Magnets
Myoglobin
Magnetic resonance
Metabolism
Nuclear magnetic resonance
deoxymyoglobin
Experiments

Keywords

  • Hemoglobin
  • Myocardium
  • Myoglobin
  • NMR
  • Oxygen

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Spatial distribution of deoxymyoglobin in human muscle : An index of local tissue oxygenation. / Tran, Tuan Khanh; Sailasuta, Napapon; Hurd, Ralph; Jue, Thomas.

In: NMR in Biomedicine, Vol. 12, No. 1, 02.1999, p. 26-30.

Research output: Contribution to journalArticle

Tran, Tuan Khanh ; Sailasuta, Napapon ; Hurd, Ralph ; Jue, Thomas. / Spatial distribution of deoxymyoglobin in human muscle : An index of local tissue oxygenation. In: NMR in Biomedicine. 1999 ; Vol. 12, No. 1. pp. 26-30.
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