Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors

Dustin E. Kruse, Douglas N. Stephens, Eric E. Paoli, Stephen H. Barnes, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

We present a new system for generating controlled tissue heating with a clinical ultrasound scanner and initial in vitro and in vivo results that demonstrate both transient and sustained heating in the mildhyperthermia range of 37-42°C. The system consists of a Siemens Antares™ ultrasound scanner, a custom dual-frequency 3-row transducer array, and an external temperature feedback control system. The transducer has 2 outer rows that operate at 1.5 MHz for tissue heating and a center row that operates at 5 MHz for B-mode imaging. Temperature measurement is accomplished using a thermocouple encased within a 29 gauge stainless steel needle. The temperature measurements are fed into a modified proportional-differential-integral (PID) control loop programmed in LabVIEW™ running on an external PC. Modifications to the PID loop include a limited bandwidth differential section and integrator anti-windup. The PID loop controls duty cycle by varying the PRF on a SIEMENS Antares ultrasound scanner, and the resulting PRF update rate is approximately 3 Hz. The heating beam is directed using the pulsed-Doppler cursor with reference to a 5 MHz B-mode image. B-mode updates also occur at approximately 3 Hz. In vitro results show differential heating of chicken breast of 8°C at the beam focus. We show that the system is able to maintain the temperature to within 0.1°C of the desired temperature both in vitro and in vivo. In vivo tests of the system were performed on a mouse bearing Met-1 tumors, which is a model of aggressive, metastatic and highly vascular breast cancer. In superficially implanted tumors, we demonstrate controlled heating to temperatures in the 39-42°C range, which is ideal for releasing drugs from thermally-sensitive liposomes.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages313-318
Number of pages6
DOIs
StatePublished - 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Other

Other2007 IEEE Ultrasonics Symposium, IUS
CountryUnited States
CityNew York, NY
Period10/28/0710/31/07

Fingerprint

Tumors
Ultrasonics
Tissue
Heating
Temperature measurement
Transducers
Bearings (structural)
Liposomes
Thermocouples
Temperature control
Needles
Temperature
Gages
Feedback control
Stainless steel
Bandwidth
Control systems
Imaging techniques

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kruse, D. E., Stephens, D. N., Paoli, E. E., Barnes, S. H., & Ferrara, K. W. (2007). Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. In Proceedings - IEEE Ultrasonics Symposium (pp. 313-318). [4409662] https://doi.org/10.1109/ULTSYM.2007.89

Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. / Kruse, Dustin E.; Stephens, Douglas N.; Paoli, Eric E.; Barnes, Stephen H.; Ferrara, Katherine W.

Proceedings - IEEE Ultrasonics Symposium. 2007. p. 313-318 4409662.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kruse, DE, Stephens, DN, Paoli, EE, Barnes, SH & Ferrara, KW 2007, Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. in Proceedings - IEEE Ultrasonics Symposium., 4409662, pp. 313-318, 2007 IEEE Ultrasonics Symposium, IUS, New York, NY, United States, 10/28/07. https://doi.org/10.1109/ULTSYM.2007.89
Kruse DE, Stephens DN, Paoli EE, Barnes SH, Ferrara KW. Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. In Proceedings - IEEE Ultrasonics Symposium. 2007. p. 313-318. 4409662 https://doi.org/10.1109/ULTSYM.2007.89
Kruse, Dustin E. ; Stephens, Douglas N. ; Paoli, Eric E. ; Barnes, Stephen H. ; Ferrara, Katherine W. / Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. Proceedings - IEEE Ultrasonics Symposium. 2007. pp. 313-318
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