Abstract
We present a new system for generating controlled tissue heating with a clinical ultrasound scanner and initial in vitro and in vivo results that demonstrate both transient and sustained heating in the mildhyperthermia range of 37-42°C. The system consists of a Siemens Antares™ ultrasound scanner, a custom dual-frequency 3-row transducer array, and an external temperature feedback control system. The transducer has 2 outer rows that operate at 1.5 MHz for tissue heating and a center row that operates at 5 MHz for B-mode imaging. Temperature measurement is accomplished using a thermocouple encased within a 29 gauge stainless steel needle. The temperature measurements are fed into a modified proportional-differential-integral (PID) control loop programmed in LabVIEW™ running on an external PC. Modifications to the PID loop include a limited bandwidth differential section and integrator anti-windup. The PID loop controls duty cycle by varying the PRF on a SIEMENS Antares ultrasound scanner, and the resulting PRF update rate is approximately 3 Hz. The heating beam is directed using the pulsed-Doppler cursor with reference to a 5 MHz B-mode image. B-mode updates also occur at approximately 3 Hz. In vitro results show differential heating of chicken breast of 8°C at the beam focus. We show that the system is able to maintain the temperature to within 0.1°C of the desired temperature both in vitro and in vivo. In vivo tests of the system were performed on a mouse bearing Met-1 tumors, which is a model of aggressive, metastatic and highly vascular breast cancer. In superficially implanted tumors, we demonstrate controlled heating to temperatures in the 39-42°C range, which is ideal for releasing drugs from thermally-sensitive liposomes.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| Pages | 313-318 |
| Number of pages | 6 |
| DOIs | |
| State | Published - 2007 |
| Event | 2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States Duration: Oct 28 2007 → Oct 31 2007 |
Other
| Other | 2007 IEEE Ultrasonics Symposium, IUS |
|---|---|
| Country | United States |
| City | New York, NY |
| Period | 10/28/07 → 10/31/07 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. / Kruse, Dustin E.; Stephens, Douglas N.; Paoli, Eric E.; Barnes, Stephen H.; Ferrara, Katherine W.
Proceedings - IEEE Ultrasonics Symposium. 2007. p. 313-318 4409662.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Spatial and temporal controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors
AU - Kruse, Dustin E.
AU - Stephens, Douglas N.
AU - Paoli, Eric E.
AU - Barnes, Stephen H.
AU - Ferrara, Katherine W.
PY - 2007
Y1 - 2007
N2 - We present a new system for generating controlled tissue heating with a clinical ultrasound scanner and initial in vitro and in vivo results that demonstrate both transient and sustained heating in the mildhyperthermia range of 37-42°C. The system consists of a Siemens Antares™ ultrasound scanner, a custom dual-frequency 3-row transducer array, and an external temperature feedback control system. The transducer has 2 outer rows that operate at 1.5 MHz for tissue heating and a center row that operates at 5 MHz for B-mode imaging. Temperature measurement is accomplished using a thermocouple encased within a 29 gauge stainless steel needle. The temperature measurements are fed into a modified proportional-differential-integral (PID) control loop programmed in LabVIEW™ running on an external PC. Modifications to the PID loop include a limited bandwidth differential section and integrator anti-windup. The PID loop controls duty cycle by varying the PRF on a SIEMENS Antares ultrasound scanner, and the resulting PRF update rate is approximately 3 Hz. The heating beam is directed using the pulsed-Doppler cursor with reference to a 5 MHz B-mode image. B-mode updates also occur at approximately 3 Hz. In vitro results show differential heating of chicken breast of 8°C at the beam focus. We show that the system is able to maintain the temperature to within 0.1°C of the desired temperature both in vitro and in vivo. In vivo tests of the system were performed on a mouse bearing Met-1 tumors, which is a model of aggressive, metastatic and highly vascular breast cancer. In superficially implanted tumors, we demonstrate controlled heating to temperatures in the 39-42°C range, which is ideal for releasing drugs from thermally-sensitive liposomes.
AB - We present a new system for generating controlled tissue heating with a clinical ultrasound scanner and initial in vitro and in vivo results that demonstrate both transient and sustained heating in the mildhyperthermia range of 37-42°C. The system consists of a Siemens Antares™ ultrasound scanner, a custom dual-frequency 3-row transducer array, and an external temperature feedback control system. The transducer has 2 outer rows that operate at 1.5 MHz for tissue heating and a center row that operates at 5 MHz for B-mode imaging. Temperature measurement is accomplished using a thermocouple encased within a 29 gauge stainless steel needle. The temperature measurements are fed into a modified proportional-differential-integral (PID) control loop programmed in LabVIEW™ running on an external PC. Modifications to the PID loop include a limited bandwidth differential section and integrator anti-windup. The PID loop controls duty cycle by varying the PRF on a SIEMENS Antares ultrasound scanner, and the resulting PRF update rate is approximately 3 Hz. The heating beam is directed using the pulsed-Doppler cursor with reference to a 5 MHz B-mode image. B-mode updates also occur at approximately 3 Hz. In vitro results show differential heating of chicken breast of 8°C at the beam focus. We show that the system is able to maintain the temperature to within 0.1°C of the desired temperature both in vitro and in vivo. In vivo tests of the system were performed on a mouse bearing Met-1 tumors, which is a model of aggressive, metastatic and highly vascular breast cancer. In superficially implanted tumors, we demonstrate controlled heating to temperatures in the 39-42°C range, which is ideal for releasing drugs from thermally-sensitive liposomes.
UR - http://www.scopus.com/inward/record.url?scp=48149101613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48149101613&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2007.89
DO - 10.1109/ULTSYM.2007.89
M3 - Conference contribution
SN - 1424413834
SN - 9781424413836
SP - 313
EP - 318
BT - Proceedings - IEEE Ultrasonics Symposium
ER -