Spared and impaired spoken discourse processing in schizophrenia

Effects of local and global language context

Tamara Y. Swaab, Megan A. Boudewyn, Debra L. Long, Steve J. Luck, Ann M. Kring, John D Ragland, Charan Ranganath, Tyler Lesh, Tara A Niendam, Marjorie Solomon Friedman, George R Mangun, Cameron S Carter

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Individuals with schizophrenia are impaired in a broad range of cognitive functions, including impairments in the controlled maintenance of context-relevant information. In this study, we used ERPs in human subjects to examine whether impairments in the controlled maintenance of spoken discourse context in schizophrenia lead to overreliance on local associations among the meanings of individual words. Healthy controls (n=22) and patients (n=22) listened to short stories in whichwemanipulated global discourse congruence and local priming. The target word in the last sentence of each story was globally congruent or incongruent and locally associated or unassociated. ERP local association effects did not significantly differ between control participants and schizophrenia patients. However, in contrast to controls, patients only showed effects of discourse congruence when targets were primed by a word in the local context. When patients had to use discourse context in the absence of local priming, they showed impaired brain responses to the target. Our findings indicate that schizophrenia patients are impaired during discourse comprehension when demands on controlled maintenance of context are high. We further found that ERP measures of increased reliance on local priming predicted reduced social functioning, suggesting that alterations in the neural mechanisms underlying discourse comprehension have functional consequences in the illness.

Original languageEnglish (US)
Pages (from-to)15578-15587
Number of pages10
JournalJournal of Neuroscience
Volume33
Issue number39
DOIs
StatePublished - 2013

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Schizophrenia
Language
Maintenance
Cognition
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Spared and impaired spoken discourse processing in schizophrenia : Effects of local and global language context. / Swaab, Tamara Y.; Boudewyn, Megan A.; Long, Debra L.; Luck, Steve J.; Kring, Ann M.; Ragland, John D; Ranganath, Charan; Lesh, Tyler; Niendam, Tara A; Friedman, Marjorie Solomon; Mangun, George R; Carter, Cameron S.

In: Journal of Neuroscience, Vol. 33, No. 39, 2013, p. 15578-15587.

Research output: Contribution to journalArticle

Swaab, Tamara Y. ; Boudewyn, Megan A. ; Long, Debra L. ; Luck, Steve J. ; Kring, Ann M. ; Ragland, John D ; Ranganath, Charan ; Lesh, Tyler ; Niendam, Tara A ; Friedman, Marjorie Solomon ; Mangun, George R ; Carter, Cameron S. / Spared and impaired spoken discourse processing in schizophrenia : Effects of local and global language context. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 39. pp. 15578-15587.
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