Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women

Ou Shu Xiao Ou Shu, F. Jin, Q. Dai, W. Wen, J. D. Potter, L. H. Kushi, Z. Ruan, Y. T. Gao, W. Zheng

Research output: Contribution to journalArticle

394 Citations (Scopus)

Abstract

Many experimental but few epidemiological studies have suggested that soyfoods and their constituents have cancer-inhibitory effects on breast cancer. No epidemiological study has evaluated the association of adolescent soyfood intake with the risk of breast cancer. To evaluate the effect of soyfood intake during adolescence, one of the periods that breast tissue is most sensitive to environmental stimuli, on subsequent risk of breast cancer, we analyzed data from a population-based case-control of 1459 breast cancer cases and 1556 age-matched controls (respective response rates were 91.1% and 90.3%). Information on dietary intake from ages 13-15 years was obtained by interview from all study participants and, in addition, from mothers of subjects less than 45 years of age (296 cases and 359 controls). Odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic models were used to measure soyfood intake and breast cancer risk. After adjustment for a variety of other risk factors, adolescent soyfood intake was inversely associated with risk, with ORs of 1.0 (reference), 0.75 (95% CI, 0.60-0.93), 0.69 (95% CI, 0.55-0.87), 0.69 (95% CI, 0.55-0.86), and 0.51 (95% CI, 0.40-0.65), respectively, for the lowest to highest quintiles of total soyfood intake (trend test, P < 0.001). The inverse association was observed for each of the soyfoods examined and existed for both pre- and postmenopausal women. Adolescent soyfood intakes reported by participants' mothers were also inversely associated with breast cancer risk (P for trend < 0.001), with an OR of 0.35 (95% CI, 0.21-0.60) for women in the highest soyfood intake group. Adjustment for rice and wheat products, the major energy source in the study population, and usual adult soyfood intake did not change the soyfood associations. Our study suggests that high soy intake during adolescence may reduce the risk of breast cancer in later life.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Breast Neoplasms
Confidence Intervals
Odds Ratio
Epidemiologic Studies
Mothers
Population
Triticum
Breast
Logistic Models
Interviews
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Xiao Ou Shu, O. S., Jin, F., Dai, Q., Wen, W., Potter, J. D., Kushi, L. H., ... Zheng, W. (2001). Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiology Biomarkers and Prevention, 10(5), 483-488.

Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. / Xiao Ou Shu, Ou Shu; Jin, F.; Dai, Q.; Wen, W.; Potter, J. D.; Kushi, L. H.; Ruan, Z.; Gao, Y. T.; Zheng, W.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 10, No. 5, 2001, p. 483-488.

Research output: Contribution to journalArticle

Xiao Ou Shu, OS, Jin, F, Dai, Q, Wen, W, Potter, JD, Kushi, LH, Ruan, Z, Gao, YT & Zheng, W 2001, 'Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women', Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 5, pp. 483-488.
Xiao Ou Shu, Ou Shu ; Jin, F. ; Dai, Q. ; Wen, W. ; Potter, J. D. ; Kushi, L. H. ; Ruan, Z. ; Gao, Y. T. ; Zheng, W. / Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. In: Cancer Epidemiology Biomarkers and Prevention. 2001 ; Vol. 10, No. 5. pp. 483-488.
@article{ab0f387eee724021b6bea04e565a697a,
title = "Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women",
abstract = "Many experimental but few epidemiological studies have suggested that soyfoods and their constituents have cancer-inhibitory effects on breast cancer. No epidemiological study has evaluated the association of adolescent soyfood intake with the risk of breast cancer. To evaluate the effect of soyfood intake during adolescence, one of the periods that breast tissue is most sensitive to environmental stimuli, on subsequent risk of breast cancer, we analyzed data from a population-based case-control of 1459 breast cancer cases and 1556 age-matched controls (respective response rates were 91.1{\%} and 90.3{\%}). Information on dietary intake from ages 13-15 years was obtained by interview from all study participants and, in addition, from mothers of subjects less than 45 years of age (296 cases and 359 controls). Odds ratios (ORs) and 95{\%} confidence intervals (CIs) derived from unconditional logistic models were used to measure soyfood intake and breast cancer risk. After adjustment for a variety of other risk factors, adolescent soyfood intake was inversely associated with risk, with ORs of 1.0 (reference), 0.75 (95{\%} CI, 0.60-0.93), 0.69 (95{\%} CI, 0.55-0.87), 0.69 (95{\%} CI, 0.55-0.86), and 0.51 (95{\%} CI, 0.40-0.65), respectively, for the lowest to highest quintiles of total soyfood intake (trend test, P < 0.001). The inverse association was observed for each of the soyfoods examined and existed for both pre- and postmenopausal women. Adolescent soyfood intakes reported by participants' mothers were also inversely associated with breast cancer risk (P for trend < 0.001), with an OR of 0.35 (95{\%} CI, 0.21-0.60) for women in the highest soyfood intake group. Adjustment for rice and wheat products, the major energy source in the study population, and usual adult soyfood intake did not change the soyfood associations. Our study suggests that high soy intake during adolescence may reduce the risk of breast cancer in later life.",
author = "{Xiao Ou Shu}, {Ou Shu} and F. Jin and Q. Dai and W. Wen and Potter, {J. D.} and Kushi, {L. H.} and Z. Ruan and Gao, {Y. T.} and W. Zheng",
year = "2001",
language = "English (US)",
volume = "10",
pages = "483--488",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women

AU - Xiao Ou Shu, Ou Shu

AU - Jin, F.

AU - Dai, Q.

AU - Wen, W.

AU - Potter, J. D.

AU - Kushi, L. H.

AU - Ruan, Z.

AU - Gao, Y. T.

AU - Zheng, W.

PY - 2001

Y1 - 2001

N2 - Many experimental but few epidemiological studies have suggested that soyfoods and their constituents have cancer-inhibitory effects on breast cancer. No epidemiological study has evaluated the association of adolescent soyfood intake with the risk of breast cancer. To evaluate the effect of soyfood intake during adolescence, one of the periods that breast tissue is most sensitive to environmental stimuli, on subsequent risk of breast cancer, we analyzed data from a population-based case-control of 1459 breast cancer cases and 1556 age-matched controls (respective response rates were 91.1% and 90.3%). Information on dietary intake from ages 13-15 years was obtained by interview from all study participants and, in addition, from mothers of subjects less than 45 years of age (296 cases and 359 controls). Odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic models were used to measure soyfood intake and breast cancer risk. After adjustment for a variety of other risk factors, adolescent soyfood intake was inversely associated with risk, with ORs of 1.0 (reference), 0.75 (95% CI, 0.60-0.93), 0.69 (95% CI, 0.55-0.87), 0.69 (95% CI, 0.55-0.86), and 0.51 (95% CI, 0.40-0.65), respectively, for the lowest to highest quintiles of total soyfood intake (trend test, P < 0.001). The inverse association was observed for each of the soyfoods examined and existed for both pre- and postmenopausal women. Adolescent soyfood intakes reported by participants' mothers were also inversely associated with breast cancer risk (P for trend < 0.001), with an OR of 0.35 (95% CI, 0.21-0.60) for women in the highest soyfood intake group. Adjustment for rice and wheat products, the major energy source in the study population, and usual adult soyfood intake did not change the soyfood associations. Our study suggests that high soy intake during adolescence may reduce the risk of breast cancer in later life.

AB - Many experimental but few epidemiological studies have suggested that soyfoods and their constituents have cancer-inhibitory effects on breast cancer. No epidemiological study has evaluated the association of adolescent soyfood intake with the risk of breast cancer. To evaluate the effect of soyfood intake during adolescence, one of the periods that breast tissue is most sensitive to environmental stimuli, on subsequent risk of breast cancer, we analyzed data from a population-based case-control of 1459 breast cancer cases and 1556 age-matched controls (respective response rates were 91.1% and 90.3%). Information on dietary intake from ages 13-15 years was obtained by interview from all study participants and, in addition, from mothers of subjects less than 45 years of age (296 cases and 359 controls). Odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic models were used to measure soyfood intake and breast cancer risk. After adjustment for a variety of other risk factors, adolescent soyfood intake was inversely associated with risk, with ORs of 1.0 (reference), 0.75 (95% CI, 0.60-0.93), 0.69 (95% CI, 0.55-0.87), 0.69 (95% CI, 0.55-0.86), and 0.51 (95% CI, 0.40-0.65), respectively, for the lowest to highest quintiles of total soyfood intake (trend test, P < 0.001). The inverse association was observed for each of the soyfoods examined and existed for both pre- and postmenopausal women. Adolescent soyfood intakes reported by participants' mothers were also inversely associated with breast cancer risk (P for trend < 0.001), with an OR of 0.35 (95% CI, 0.21-0.60) for women in the highest soyfood intake group. Adjustment for rice and wheat products, the major energy source in the study population, and usual adult soyfood intake did not change the soyfood associations. Our study suggests that high soy intake during adolescence may reduce the risk of breast cancer in later life.

UR - http://www.scopus.com/inward/record.url?scp=0034914622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034914622&partnerID=8YFLogxK

M3 - Article

C2 - 11352858

AN - SCOPUS:0034914622

VL - 10

SP - 483

EP - 488

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 5

ER -